Overall survival and second primary malignancies in men with metastatic prostate cancer.
BACKGROUND:Among prostate cancer (PC) patients, over 90% of distant metastases occur in the bone. PC treatments may be associated with side effects, including second primary malignancies (SPM). There is limited information on the incidence of SPM among men with bone metastatic PC (mPC) and among men...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0227552 |
| _version_ | 1818403353437143040 |
|---|---|
| author | Juha Mehtälä Jihong Zong Zdravko Vassilev Gunnar Brobert Montse Soriano Gabarró Pär Stattin Houssem Khanfir |
| author_facet | Juha Mehtälä Jihong Zong Zdravko Vassilev Gunnar Brobert Montse Soriano Gabarró Pär Stattin Houssem Khanfir |
| author_sort | Juha Mehtälä |
| collection | DOAJ |
| description | BACKGROUND:Among prostate cancer (PC) patients, over 90% of distant metastases occur in the bone. PC treatments may be associated with side effects, including second primary malignancies (SPM). There is limited information on the incidence of SPM among men with bone metastatic PC (mPC) and among men with bone metastatic castration-resistant PC (mCRPC). We estimated overall survival and the incidence of SPM in men with mPC and mCRPC. METHODS:In the Prostate Cancer data Base Sweden, the National Prostate Cancer Register was linked to other national health care registers, 15,953 men with mPC in 1999-2011 were identified. Further, 693 men with mCRPC were identified. Outcomes were evaluated using stratified incidence rates, Kaplan-Meier estimators and Cox models. RESULTS:The mean age among men with mPC was 73.9 years and in men with mCRPC 70.0 years. The median respective survivals were 1.5 (13,965 deaths) and 1.14 years (599 deaths), and average times since PC diagnosis 1.8 and 4.7 years. We observed 2,669 SPMs in men with mPC and 100 SPMs in men with mCRPC. The incidence rate of SPM per 1,000 person-years was 81.8 (78.8-85.0) for mPC and 115.6 (95.1-140.7) for mCRPC. High age, prior neoplasms, urinary tract infection, congestive heart failure, diabetes and renal disease were most strongly associated with increased mortality risk. Prior neoplasms and prior use of antineoplastic agents were most strongly associated with increased SPM risk. Several factors associated with increased mortality and SPM risks were more prevalent in the mCRPC cohort. CONCLUSIONS:Our results on mortality for men with mPC and mCRPC are in line with previous studies from the same time period. Investigation of factors associated with mortality and SPM in men with mPC and mCRPC can help to further understand these outcomes in the era prior to several new treatments have come available. |
| first_indexed | 2024-12-14T08:22:55Z |
| format | Article |
| id | doaj.art-e83d93f64e39495a97f8ca7bcecd8cbd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:22:55Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e83d93f64e39495a97f8ca7bcecd8cbd2022-12-21T23:09:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01152e022755210.1371/journal.pone.0227552Overall survival and second primary malignancies in men with metastatic prostate cancer.Juha MehtäläJihong ZongZdravko VassilevGunnar BrobertMontse Soriano GabarróPär StattinHoussem KhanfirBACKGROUND:Among prostate cancer (PC) patients, over 90% of distant metastases occur in the bone. PC treatments may be associated with side effects, including second primary malignancies (SPM). There is limited information on the incidence of SPM among men with bone metastatic PC (mPC) and among men with bone metastatic castration-resistant PC (mCRPC). We estimated overall survival and the incidence of SPM in men with mPC and mCRPC. METHODS:In the Prostate Cancer data Base Sweden, the National Prostate Cancer Register was linked to other national health care registers, 15,953 men with mPC in 1999-2011 were identified. Further, 693 men with mCRPC were identified. Outcomes were evaluated using stratified incidence rates, Kaplan-Meier estimators and Cox models. RESULTS:The mean age among men with mPC was 73.9 years and in men with mCRPC 70.0 years. The median respective survivals were 1.5 (13,965 deaths) and 1.14 years (599 deaths), and average times since PC diagnosis 1.8 and 4.7 years. We observed 2,669 SPMs in men with mPC and 100 SPMs in men with mCRPC. The incidence rate of SPM per 1,000 person-years was 81.8 (78.8-85.0) for mPC and 115.6 (95.1-140.7) for mCRPC. High age, prior neoplasms, urinary tract infection, congestive heart failure, diabetes and renal disease were most strongly associated with increased mortality risk. Prior neoplasms and prior use of antineoplastic agents were most strongly associated with increased SPM risk. Several factors associated with increased mortality and SPM risks were more prevalent in the mCRPC cohort. CONCLUSIONS:Our results on mortality for men with mPC and mCRPC are in line with previous studies from the same time period. Investigation of factors associated with mortality and SPM in men with mPC and mCRPC can help to further understand these outcomes in the era prior to several new treatments have come available.https://doi.org/10.1371/journal.pone.0227552 |
| spellingShingle | Juha Mehtälä Jihong Zong Zdravko Vassilev Gunnar Brobert Montse Soriano Gabarró Pär Stattin Houssem Khanfir Overall survival and second primary malignancies in men with metastatic prostate cancer. PLoS ONE |
| title | Overall survival and second primary malignancies in men with metastatic prostate cancer. |
| title_full | Overall survival and second primary malignancies in men with metastatic prostate cancer. |
| title_fullStr | Overall survival and second primary malignancies in men with metastatic prostate cancer. |
| title_full_unstemmed | Overall survival and second primary malignancies in men with metastatic prostate cancer. |
| title_short | Overall survival and second primary malignancies in men with metastatic prostate cancer. |
| title_sort | overall survival and second primary malignancies in men with metastatic prostate cancer |
| url | https://doi.org/10.1371/journal.pone.0227552 |
| work_keys_str_mv | AT juhamehtala overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT jihongzong overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT zdravkovassilev overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT gunnarbrobert overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT montsesorianogabarro overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT parstattin overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer AT houssemkhanfir overallsurvivalandsecondprimarymalignanciesinmenwithmetastaticprostatecancer |