Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia
Purpose: This study evaluated serum amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and echocardiography to determine their efficacy as markers for predicting postpartum pulmonary edema in patients with severe preeclampsia. Methods: We evaluated the NT-proBNP levels and echocardiogr...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5301 |
| _version_ | 1828748005499469824 |
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| author | H.M. Kim Y.S. Choo W.J. Seong |
| author_facet | H.M. Kim Y.S. Choo W.J. Seong |
| author_sort | H.M. Kim |
| collection | DOAJ |
| description | Purpose: This study evaluated serum amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and echocardiography to determine their efficacy as markers for predicting postpartum pulmonary edema in patients with severe preeclampsia. Methods: We evaluated the NT-proBNP levels and echocardiographic results of 124 preeclamptic women (gestation preeclampsia (GPE) group, n = 77; superimposed preeclampsia on underlying hypertension (SPE) group n = 47). Patients were also divided into postpartum pulmonary edema (PPE, n = 28) and non-pulmonary edema (NPE, n = 96) groups. NT-proBNP levels and echocardiographic parameters were compared between groups, and their correlations were also evaluated. Statistical analysis was carried out using variance analysis, and significance was set at p < 0.05. Results: The SPE group had significantly higher NT-proBNP levels than the GPE group. They were also more likely to have PPE, but this was not significant. Echocardiography showed no significant differences in the left ventricular (LV) ejection fraction (LVEF) of the two groups, but a mild LV diastolic dysfunction was noted in the SPE group. The PPE group had significantly higher serum NT-proBNP levels and lower LVEF than the NPE group. There were no significant differences in the echocardiographic parameters of diastolic cardiac dysfunction in the two groups. The serum NT-proBNP levels were significantly negatively correlated with LVEF. Conclusions: PPE in patients with severe preeclampsia was associated with impaired cardiac function, especially LV systolic dysfunction. Serum NT-proBNP levels and echocardiography may be useful predictive markers for postpartum pulmonary edema in women with severe preeclampsia. |
| first_indexed | 2024-04-14T04:52:33Z |
| format | Article |
| id | doaj.art-e8405adfa50e4f41b97929633cc6ceed |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-14T04:52:33Z |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-e8405adfa50e4f41b97929633cc6ceed2022-12-22T02:11:14ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147451151510.31083/j.ceog.2020.04.5301S0390-6663(20)00300-0Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsiaH.M. Kim0Y.S. Choo1W.J. Seong2Department of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, Daegu, 41404, Republic of KoreaDepartment of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of KoreaDepartment of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, Daegu, 41404, Republic of KoreaPurpose: This study evaluated serum amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and echocardiography to determine their efficacy as markers for predicting postpartum pulmonary edema in patients with severe preeclampsia. Methods: We evaluated the NT-proBNP levels and echocardiographic results of 124 preeclamptic women (gestation preeclampsia (GPE) group, n = 77; superimposed preeclampsia on underlying hypertension (SPE) group n = 47). Patients were also divided into postpartum pulmonary edema (PPE, n = 28) and non-pulmonary edema (NPE, n = 96) groups. NT-proBNP levels and echocardiographic parameters were compared between groups, and their correlations were also evaluated. Statistical analysis was carried out using variance analysis, and significance was set at p < 0.05. Results: The SPE group had significantly higher NT-proBNP levels than the GPE group. They were also more likely to have PPE, but this was not significant. Echocardiography showed no significant differences in the left ventricular (LV) ejection fraction (LVEF) of the two groups, but a mild LV diastolic dysfunction was noted in the SPE group. The PPE group had significantly higher serum NT-proBNP levels and lower LVEF than the NPE group. There were no significant differences in the echocardiographic parameters of diastolic cardiac dysfunction in the two groups. The serum NT-proBNP levels were significantly negatively correlated with LVEF. Conclusions: PPE in patients with severe preeclampsia was associated with impaired cardiac function, especially LV systolic dysfunction. Serum NT-proBNP levels and echocardiography may be useful predictive markers for postpartum pulmonary edema in women with severe preeclampsia.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5301nt-probnppreeclampsiaechocardiographypulmonary edemacardiac function |
| spellingShingle | H.M. Kim Y.S. Choo W.J. Seong Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia Clinical and Experimental Obstetrics & Gynecology nt-probnp preeclampsia echocardiography pulmonary edema cardiac function |
| title | Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia |
| title_full | Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia |
| title_fullStr | Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia |
| title_full_unstemmed | Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia |
| title_short | Serum NT-proBNP levels as a marker for cardiopulmonary function in preeclampsia |
| title_sort | serum nt probnp levels as a marker for cardiopulmonary function in preeclampsia |
| topic | nt-probnp preeclampsia echocardiography pulmonary edema cardiac function |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5301 |
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