A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence
Abstract Aim This prospective, randomized, controlled, rater‐blinded study investigated the effect of G protein‐activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. Methods The participants were 68 outpatients with alcohol de...
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| Format: | Article |
| Language: | English |
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Wiley
2018-03-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12001 |
| _version_ | 1828091239579254784 |
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| author | Nagisa Sugaya Yasukazu Ogai Yuzo Aikawa Yosuke Yumoto Mihoko Takahama Miho Tanaka Ayako Haraguchi Mitsuru Umeno Kazutaka Ikeda |
| author_facet | Nagisa Sugaya Yasukazu Ogai Yuzo Aikawa Yosuke Yumoto Mihoko Takahama Miho Tanaka Ayako Haraguchi Mitsuru Umeno Kazutaka Ikeda |
| author_sort | Nagisa Sugaya |
| collection | DOAJ |
| description | Abstract Aim This prospective, randomized, controlled, rater‐blinded study investigated the effect of G protein‐activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. Methods The participants were 68 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil per day for 3 months) or control group (administered 600 mg ascorbic acid and calcium pantothenate per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol use score was calculated using these two items. Results Valid data were obtained from 46 participants (25 in the ifenprodil group and 21 in the control group). The alcohol use score at time 2 in the ifenprodil group was significantly lower than that in the control group after adjusting for the score at time 1 and some covariates. The intention‐to‐treat analysis of multiply imputed datasets indicated similar results. Group differences in the frequency of alcohol drinking were significant in the multiply imputed datasets but not in 46 participants. The ifenprodil group had a significantly lower rate of heavy drinking at time 2 than the control group. Conclusions This study found an inhibitory effect of ifenprodil on alcohol use in patients with alcohol dependence. The results support the hypothesis that GIRK channel inhibitors ameliorate alcohol dependence. Trial registry This trial was registered in the UMIN clinical trial registry (UMIN000006347). |
| first_indexed | 2024-04-11T06:10:17Z |
| format | Article |
| id | doaj.art-e841f13bab254415978f11b109bbb317 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T06:10:17Z |
| publishDate | 2018-03-01 |
| publisher | Wiley |
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| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-e841f13bab254415978f11b109bbb3172022-12-22T04:41:19ZengWileyNeuropsychopharmacology Reports2574-173X2018-03-0138191710.1002/npr2.12001A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependenceNagisa Sugaya0Yasukazu Ogai1Yuzo Aikawa2Yosuke Yumoto3Mihoko Takahama4Miho Tanaka5Ayako Haraguchi6Mitsuru Umeno7Kazutaka Ikeda8Addictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanTokyo Metropolitan Matsuzawa Hospital Tokyo JapanTokyo Metropolitan Matsuzawa Hospital Tokyo JapanTokyo Metropolitan Matsuzawa Hospital Tokyo JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanTokyo Metropolitan Matsuzawa Hospital Tokyo JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanAbstract Aim This prospective, randomized, controlled, rater‐blinded study investigated the effect of G protein‐activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. Methods The participants were 68 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil per day for 3 months) or control group (administered 600 mg ascorbic acid and calcium pantothenate per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol use score was calculated using these two items. Results Valid data were obtained from 46 participants (25 in the ifenprodil group and 21 in the control group). The alcohol use score at time 2 in the ifenprodil group was significantly lower than that in the control group after adjusting for the score at time 1 and some covariates. The intention‐to‐treat analysis of multiply imputed datasets indicated similar results. Group differences in the frequency of alcohol drinking were significant in the multiply imputed datasets but not in 46 participants. The ifenprodil group had a significantly lower rate of heavy drinking at time 2 than the control group. Conclusions This study found an inhibitory effect of ifenprodil on alcohol use in patients with alcohol dependence. The results support the hypothesis that GIRK channel inhibitors ameliorate alcohol dependence. Trial registry This trial was registered in the UMIN clinical trial registry (UMIN000006347).https://doi.org/10.1002/npr2.12001alcohol dependencealcohol useG protein‐activated inwardly rectifying potassium channelifenprodilrandomized controlled study |
| spellingShingle | Nagisa Sugaya Yasukazu Ogai Yuzo Aikawa Yosuke Yumoto Mihoko Takahama Miho Tanaka Ayako Haraguchi Mitsuru Umeno Kazutaka Ikeda A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence Neuropsychopharmacology Reports alcohol dependence alcohol use G protein‐activated inwardly rectifying potassium channel ifenprodil randomized controlled study |
| title | A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| title_full | A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| title_fullStr | A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| title_full_unstemmed | A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| title_short | A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| title_sort | randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence |
| topic | alcohol dependence alcohol use G protein‐activated inwardly rectifying potassium channel ifenprodil randomized controlled study |
| url | https://doi.org/10.1002/npr2.12001 |
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