Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review
Abstract Introduction Intrastromal lenticule implantation is a promising treatment option for corneal pathologies, from refractive error to ectasia. In this narrative review, we intend to feature up-to-date literature supporting the use of lenticular tissue, a compelling method that can be customize...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2023-07-01
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| Series: | Ophthalmology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40123-023-00765-2 |
| _version_ | 1827859813628903424 |
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| author | Majid Moshirfar Isabella M. Stoakes Elayna G. Bruce Amir Ali Carter J. Payne David Furhiman Yasmyne C. Ronquillo Phillip C. Hoopes |
| author_facet | Majid Moshirfar Isabella M. Stoakes Elayna G. Bruce Amir Ali Carter J. Payne David Furhiman Yasmyne C. Ronquillo Phillip C. Hoopes |
| author_sort | Majid Moshirfar |
| collection | DOAJ |
| description | Abstract Introduction Intrastromal lenticule implantation is a promising treatment option for corneal pathologies, from refractive error to ectasia. In this narrative review, we intend to feature up-to-date literature supporting the use of lenticular tissue, a compelling method that can be customized for a variety of applications, providing an additional source of donor tissue for treating corneal diseases. Methods We searched databases PubMed, Mendeley, and Scopus last accessed 10 May 2023, for literature on stromal lenticules and narrowed based on relevance. Review articles, animal studies, ex vivo studies, and book chapters were excluded, while assessable and relevant articles published in English were included. Results Storage methods from using fresh lenticules to dehydration have proven successful, with cryopreservation maintaining structure and cellular viability for up to 10 years. Successful use of lenticules for treatment of numerous pathologies including corneal ectasias, hyperopia, and presbyopia with additional insight into the treatment of corneal ulcers and perforations are highlighted in this narrative review. Conclusion Lenticular implantation is an innovative and advantageous treatment for various ocular pathologies, offering increased bioavailability, flexibility, and customization for patients. They can treat previously untreatable diseases and serve as a replacement for synthetic implants, with promising outcomes worldwide. Lenticular implantation has the potential to become a leading approach in ophthalmologic surgery. Further studies should aim to provide evidentiary support for a standardization of lenticule banking. |
| first_indexed | 2024-03-12T13:14:00Z |
| format | Article |
| id | doaj.art-e842234b2cdb46b9b4793c4c9052d714 |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-03-12T13:14:00Z |
| publishDate | 2023-07-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-e842234b2cdb46b9b4793c4c9052d7142023-08-27T11:11:46ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-07-011252361237910.1007/s40123-023-00765-2Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative ReviewMajid Moshirfar0Isabella M. Stoakes1Elayna G. Bruce2Amir Ali3Carter J. Payne4David Furhiman5Yasmyne C. Ronquillo6Phillip C. Hoopes7HDR Research Center, Hoopes VisionHDR Research Center, Hoopes VisionMcGovern Medical SchoolUniversity of Texas Medical Branch at GalvestonHDR Research Center, Hoopes VisionMcGovern Medical SchoolHDR Research Center, Hoopes VisionHDR Research Center, Hoopes VisionAbstract Introduction Intrastromal lenticule implantation is a promising treatment option for corneal pathologies, from refractive error to ectasia. In this narrative review, we intend to feature up-to-date literature supporting the use of lenticular tissue, a compelling method that can be customized for a variety of applications, providing an additional source of donor tissue for treating corneal diseases. Methods We searched databases PubMed, Mendeley, and Scopus last accessed 10 May 2023, for literature on stromal lenticules and narrowed based on relevance. Review articles, animal studies, ex vivo studies, and book chapters were excluded, while assessable and relevant articles published in English were included. Results Storage methods from using fresh lenticules to dehydration have proven successful, with cryopreservation maintaining structure and cellular viability for up to 10 years. Successful use of lenticules for treatment of numerous pathologies including corneal ectasias, hyperopia, and presbyopia with additional insight into the treatment of corneal ulcers and perforations are highlighted in this narrative review. Conclusion Lenticular implantation is an innovative and advantageous treatment for various ocular pathologies, offering increased bioavailability, flexibility, and customization for patients. They can treat previously untreatable diseases and serve as a replacement for synthetic implants, with promising outcomes worldwide. Lenticular implantation has the potential to become a leading approach in ophthalmologic surgery. Further studies should aim to provide evidentiary support for a standardization of lenticule banking.https://doi.org/10.1007/s40123-023-00765-2Allogenic lenticule implantationIntrastromal keratoplastyPEARLCAIRSALKNecklace lenticule |
| spellingShingle | Majid Moshirfar Isabella M. Stoakes Elayna G. Bruce Amir Ali Carter J. Payne David Furhiman Yasmyne C. Ronquillo Phillip C. Hoopes Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review Ophthalmology and Therapy Allogenic lenticule implantation Intrastromal keratoplasty PEARL CAIRS ALK Necklace lenticule |
| title | Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review |
| title_full | Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review |
| title_fullStr | Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review |
| title_full_unstemmed | Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review |
| title_short | Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review |
| title_sort | allogenic lenticular implantation for correction of refractive error and ectasia narrative review |
| topic | Allogenic lenticule implantation Intrastromal keratoplasty PEARL CAIRS ALK Necklace lenticule |
| url | https://doi.org/10.1007/s40123-023-00765-2 |
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