Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review
Abstract Background Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before. Case presentation We present a case of propylthiouracil (PTU)-induced DIHS, which included fever,...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-022-00707-w |
| _version_ | 1798038076302295040 |
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| author | Fang Wu Ting Jin Chengxin Shang Xihua Lin Xiaoqin Gong Zhou Wang |
| author_facet | Fang Wu Ting Jin Chengxin Shang Xihua Lin Xiaoqin Gong Zhou Wang |
| author_sort | Fang Wu |
| collection | DOAJ |
| description | Abstract Background Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before. Case presentation We present a case of propylthiouracil (PTU)-induced DIHS, which included fever, skin rash, lymphadenopathy, hepatosplenomegaly, serious liver and kidney dysfunction, peripheral blood eosinophilia, and atypical lymphocytosis. Following supportive therapy, intravenous immunoglobulin (IVIG), and systemic corticosteroid, the patient experienced a resolution of fever and rash combined with progressive normalization of hematological index and organ function. These clinical features, and the skin lesion biopsy confirmed DIHS diagnosis. Conclusions To our knowledge, this is the second reported case of PTU-induced DIHS worldwide and the first human leukocyte antigen (HLA) typing of PTU-induced DIHS. Clinicians should cautiously distinguish hyperthyroidism etiology and identify the indication of ATDs. Timely recognition and formal DIHS treatment are required in patients with ATDs. |
| first_indexed | 2024-04-11T21:35:17Z |
| format | Article |
| id | doaj.art-e84224f277d94f24869c172ef2d3d456 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-11T21:35:17Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-e84224f277d94f24869c172ef2d3d4562022-12-22T04:01:46ZengBMCAllergy, Asthma & Clinical Immunology1710-14922022-08-011811610.1186/s13223-022-00707-wDrug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature reviewFang Wu0Ting Jin1Chengxin Shang2Xihua Lin3Xiaoqin Gong4Zhou Wang5Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw HospitalDepartment of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw HospitalDepartment of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw HospitalDepartment of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw HospitalDepartment of Gynecology, Pujiang People HospitalDepartment of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw HospitalAbstract Background Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before. Case presentation We present a case of propylthiouracil (PTU)-induced DIHS, which included fever, skin rash, lymphadenopathy, hepatosplenomegaly, serious liver and kidney dysfunction, peripheral blood eosinophilia, and atypical lymphocytosis. Following supportive therapy, intravenous immunoglobulin (IVIG), and systemic corticosteroid, the patient experienced a resolution of fever and rash combined with progressive normalization of hematological index and organ function. These clinical features, and the skin lesion biopsy confirmed DIHS diagnosis. Conclusions To our knowledge, this is the second reported case of PTU-induced DIHS worldwide and the first human leukocyte antigen (HLA) typing of PTU-induced DIHS. Clinicians should cautiously distinguish hyperthyroidism etiology and identify the indication of ATDs. Timely recognition and formal DIHS treatment are required in patients with ATDs.https://doi.org/10.1186/s13223-022-00707-wDrug-induced hypersensitivity syndromePropylthiouracilHuman leukocyte antigen |
| spellingShingle | Fang Wu Ting Jin Chengxin Shang Xihua Lin Xiaoqin Gong Zhou Wang Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review Allergy, Asthma & Clinical Immunology Drug-induced hypersensitivity syndrome Propylthiouracil Human leukocyte antigen |
| title | Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review |
| title_full | Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review |
| title_fullStr | Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review |
| title_full_unstemmed | Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review |
| title_short | Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review |
| title_sort | drug induced hypersensitivity syndrome induced by propylthiouracil case report and literature review |
| topic | Drug-induced hypersensitivity syndrome Propylthiouracil Human leukocyte antigen |
| url | https://doi.org/10.1186/s13223-022-00707-w |
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