Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition
The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.928399/full |
| _version_ | 1811242797743734784 |
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| author | Oleg Semenov Alexandra Daks Olga Fedorova Oleg Shuvalov Nickolai A. Barlev Nickolai A. Barlev Nickolai A. Barlev |
| author_facet | Oleg Semenov Alexandra Daks Olga Fedorova Oleg Shuvalov Nickolai A. Barlev Nickolai A. Barlev Nickolai A. Barlev |
| author_sort | Oleg Semenov |
| collection | DOAJ |
| description | The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT. |
| first_indexed | 2024-04-12T13:56:23Z |
| format | Article |
| id | doaj.art-e846ebed883b42fabb8024dd793253d3 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-12T13:56:23Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-e846ebed883b42fabb8024dd793253d32022-12-22T03:30:22ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-06-01910.3389/fmolb.2022.928399928399Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal TransitionOleg Semenov0Alexandra Daks1Olga Fedorova2Oleg Shuvalov3Nickolai A. Barlev4Nickolai A. Barlev5Nickolai A. Barlev6Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, RussiaRegulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, RussiaRegulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, RussiaRegulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, RussiaRegulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, RussiaLaboratory of Intracellular Signalling, Moscow Institute of Physics and Technology, Dolgoprudny, RussiaThe Group of Targeted Delivery Mechanisms of Nanosystems, Institute of Biomedical Chemistry, Moscow, RussiaThe central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT.https://www.frontiersin.org/articles/10.3389/fmolb.2022.928399/fullp53wild-type p53mutant p53EMTepithelial to mesenchymal transitionmicroRNA |
| spellingShingle | Oleg Semenov Alexandra Daks Olga Fedorova Oleg Shuvalov Nickolai A. Barlev Nickolai A. Barlev Nickolai A. Barlev Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition Frontiers in Molecular Biosciences p53 wild-type p53 mutant p53 EMT epithelial to mesenchymal transition microRNA |
| title | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
| title_full | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
| title_fullStr | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
| title_full_unstemmed | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
| title_short | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
| title_sort | opposing roles of wild type and mutant p53 in the process of epithelial to mesenchymal transition |
| topic | p53 wild-type p53 mutant p53 EMT epithelial to mesenchymal transition microRNA |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.928399/full |
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