Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool
(1) Purpose: To compare the diagnostic accuracy between full multiparametric contrast-enhanced prostate MRI (mpMRI) and abbreviated dual-sequence prostate MRI (dsMRI) in men with clinically significant prostate cancer (csPCa) who were candidates for active surveillance. (2) Materials and Methods: Fi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/578 |
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| author | Fabio Zattoni Silvio Maresca Fabrizio Dal Moro Iliana Bednarova Gianmarco Randazzo Giovanni Basso Giuseppe Reitano Gianluca Giannarini Chiara Zuiani Rossano Girometti |
| author_facet | Fabio Zattoni Silvio Maresca Fabrizio Dal Moro Iliana Bednarova Gianmarco Randazzo Giovanni Basso Giuseppe Reitano Gianluca Giannarini Chiara Zuiani Rossano Girometti |
| author_sort | Fabio Zattoni |
| collection | DOAJ |
| description | (1) Purpose: To compare the diagnostic accuracy between full multiparametric contrast-enhanced prostate MRI (mpMRI) and abbreviated dual-sequence prostate MRI (dsMRI) in men with clinically significant prostate cancer (csPCa) who were candidates for active surveillance. (2) Materials and Methods: Fifty-four patients with a diagnosis of low-risk PCa in the previous 6 months had a mpMRI scan prior to a saturation biopsy and a subsequent MRI cognitive transperineal targeted biopsy (for PI-RADS ≥ 3 lesions). The dsMRI images were obtained from the mpMRI protocol. The images were selected by a study coordinator and assigned to two readers blinded to the biopsy results (R1 and R2). Inter-reader agreement for clinically significant cancer was evaluated with Cohen’s kappa. The dsMRI and mpMRI accuracy was calculated for each reader (R1 and R2). The clinical utility of the dsMRI and mpMRI was investigated with a decision-analysis model. (3) Results: The dsMRI sensitivity and specificity were 83.3%, 31.0%, 75.0%, and 23.8%, respectively, for R1 and R2. The mpMRI sensitivity and specificity were 91.7%, 31.0%, 83.3%, and 23.8%, respectively, for R1 and R2. The inter-reader agreement for the detection of csPCa was moderate (k = 0.53) and good (k = 0.63) for dsMRI and mpMRI, respectively. The AUC values for the dsMRI were 0.77 and 0.62 for the R1 and R2, respectively. The AUC values for the mpMRI were 0.79 and 0.66 for R1 and R2, respectively. No AUC differences were found between the two MRI protocols. At any risk threshold, the mpMRI showed a higher net benefit than the dsMRI for both R1 and R2. (4) Conclusions: The dsMRI and mpMRI showed similar diagnostic accuracy for csPCa in male candidates for active surveillance. |
| first_indexed | 2024-03-11T08:57:26Z |
| format | Article |
| id | doaj.art-e84920d006d7496e98854a6efe19a17e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:57:26Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e84920d006d7496e98854a6efe19a17e2023-11-16T19:59:54ZengMDPI AGDiagnostics2075-44182023-02-0113457810.3390/diagnostics13040578Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional ToolFabio Zattoni0Silvio Maresca1Fabrizio Dal Moro2Iliana Bednarova3Gianmarco Randazzo4Giovanni Basso5Giuseppe Reitano6Gianluca Giannarini7Chiara Zuiani8Rossano Girometti9Department Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, 35122 Padova, ItalyDepartment of Medicine, Institute of Radiology, University of Udine, Santa Maria della Misericordia University Hospital, 33100 Udine, ItalyDepartment Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, 35122 Padova, ItalyDepartment of Breast Radiology, Veneto Institute of Oncology, IRCCS, 35128 Padua, ItalyDepartment Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, 35122 Padova, ItalyDepartment Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, 35122 Padova, ItalyDepartment Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, 35122 Padova, ItalyUrology Unit, Santa Maria della Misericordia University Hospital, 33100 Udine, ItalyDepartment of Medicine, Institute of Radiology, University of Udine, Santa Maria della Misericordia University Hospital, 33100 Udine, ItalyDepartment of Medicine, Institute of Radiology, University of Udine, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy(1) Purpose: To compare the diagnostic accuracy between full multiparametric contrast-enhanced prostate MRI (mpMRI) and abbreviated dual-sequence prostate MRI (dsMRI) in men with clinically significant prostate cancer (csPCa) who were candidates for active surveillance. (2) Materials and Methods: Fifty-four patients with a diagnosis of low-risk PCa in the previous 6 months had a mpMRI scan prior to a saturation biopsy and a subsequent MRI cognitive transperineal targeted biopsy (for PI-RADS ≥ 3 lesions). The dsMRI images were obtained from the mpMRI protocol. The images were selected by a study coordinator and assigned to two readers blinded to the biopsy results (R1 and R2). Inter-reader agreement for clinically significant cancer was evaluated with Cohen’s kappa. The dsMRI and mpMRI accuracy was calculated for each reader (R1 and R2). The clinical utility of the dsMRI and mpMRI was investigated with a decision-analysis model. (3) Results: The dsMRI sensitivity and specificity were 83.3%, 31.0%, 75.0%, and 23.8%, respectively, for R1 and R2. The mpMRI sensitivity and specificity were 91.7%, 31.0%, 83.3%, and 23.8%, respectively, for R1 and R2. The inter-reader agreement for the detection of csPCa was moderate (k = 0.53) and good (k = 0.63) for dsMRI and mpMRI, respectively. The AUC values for the dsMRI were 0.77 and 0.62 for the R1 and R2, respectively. The AUC values for the mpMRI were 0.79 and 0.66 for R1 and R2, respectively. No AUC differences were found between the two MRI protocols. At any risk threshold, the mpMRI showed a higher net benefit than the dsMRI for both R1 and R2. (4) Conclusions: The dsMRI and mpMRI showed similar diagnostic accuracy for csPCa in male candidates for active surveillance.https://www.mdpi.com/2075-4418/13/4/578prostate MRIprostate canceractive surveillancemultiparametric MRIabbreviated MRI protocol |
| spellingShingle | Fabio Zattoni Silvio Maresca Fabrizio Dal Moro Iliana Bednarova Gianmarco Randazzo Giovanni Basso Giuseppe Reitano Gianluca Giannarini Chiara Zuiani Rossano Girometti Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool Diagnostics prostate MRI prostate cancer active surveillance multiparametric MRI abbreviated MRI protocol |
| title | Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool |
| title_full | Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool |
| title_fullStr | Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool |
| title_full_unstemmed | Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool |
| title_short | Abbreviated Versus Multiparametric Prostate MRI in Active Surveillance for Prostate-Cancer Patients: Comparison of Accuracy and Clinical Utility as a Decisional Tool |
| title_sort | abbreviated versus multiparametric prostate mri in active surveillance for prostate cancer patients comparison of accuracy and clinical utility as a decisional tool |
| topic | prostate MRI prostate cancer active surveillance multiparametric MRI abbreviated MRI protocol |
| url | https://www.mdpi.com/2075-4418/13/4/578 |
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