HELLP Syndrome—Holistic Insight into Pathophysiology
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/2/326 |
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| author | Aida Petca Bianca Corina Miron Irina Pacu Mihai Cristian Dumitrașcu Claudia Mehedințu Florica Șandru Răzvan-Cosmin Petca Ioana Cristina Rotar |
| author_facet | Aida Petca Bianca Corina Miron Irina Pacu Mihai Cristian Dumitrașcu Claudia Mehedințu Florica Șandru Răzvan-Cosmin Petca Ioana Cristina Rotar |
| author_sort | Aida Petca |
| collection | DOAJ |
| description | HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition. |
| first_indexed | 2024-03-09T21:29:02Z |
| format | Article |
| id | doaj.art-e84aacfda14b4837b036490055251af8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:29:02Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e84aacfda14b4837b036490055251af82023-11-23T21:01:38ZengMDPI AGMedicina1010-660X1648-91442022-02-0158232610.3390/medicina58020326HELLP Syndrome—Holistic Insight into PathophysiologyAida Petca0Bianca Corina Miron1Irina Pacu2Mihai Cristian Dumitrașcu3Claudia Mehedințu4Florica Șandru5Răzvan-Cosmin Petca6Ioana Cristina Rotar7“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaHELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition.https://www.mdpi.com/1648-9144/58/2/326HELLPpathogenesismicroangiopathygeneticplacentaDIC |
| spellingShingle | Aida Petca Bianca Corina Miron Irina Pacu Mihai Cristian Dumitrașcu Claudia Mehedințu Florica Șandru Răzvan-Cosmin Petca Ioana Cristina Rotar HELLP Syndrome—Holistic Insight into Pathophysiology Medicina HELLP pathogenesis microangiopathy genetic placenta DIC |
| title | HELLP Syndrome—Holistic Insight into Pathophysiology |
| title_full | HELLP Syndrome—Holistic Insight into Pathophysiology |
| title_fullStr | HELLP Syndrome—Holistic Insight into Pathophysiology |
| title_full_unstemmed | HELLP Syndrome—Holistic Insight into Pathophysiology |
| title_short | HELLP Syndrome—Holistic Insight into Pathophysiology |
| title_sort | hellp syndrome holistic insight into pathophysiology |
| topic | HELLP pathogenesis microangiopathy genetic placenta DIC |
| url | https://www.mdpi.com/1648-9144/58/2/326 |
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