PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a major pathological characteristic of Parkinson's disease (PD). These fibrillar structures can act as seeds and accelerate the aggreg...

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Bibliographic Details
Main Authors: Majken B. Thomsen, Sara A. Ferreira, Anna C. Schacht, Jan Jacobsen, Mette Simonsen, Cristine Betzer, Poul H. Jensen, David J. Brooks, Anne M. Landau, Marina Romero-Ramos
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Neurobiology of Disease
Subjects:
PET
UCB-J
DTBZ
a-synuclein
Preformed fibrils
Parkinson
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120305040

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