Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease
Objective: Patients with normal pressure hydrocephalus (NPH) and Parkinson's Disease (PD) can clinically appear quite similar at baseline evaluation. We sought to investigate the use of kinematic assessment of postural instability (PI) using inertial measurement units (IMUs) as a mechanism of d...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724000309 |
| _version_ | 1797279291427258368 |
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| author | Jacob T. Hanson Luke T. Sabal James N. Jean Alec Jonason Reid Johnson Thomas Lisko Yeng Moua Robert A. McGovern |
| author_facet | Jacob T. Hanson Luke T. Sabal James N. Jean Alec Jonason Reid Johnson Thomas Lisko Yeng Moua Robert A. McGovern |
| author_sort | Jacob T. Hanson |
| collection | DOAJ |
| description | Objective: Patients with normal pressure hydrocephalus (NPH) and Parkinson's Disease (PD) can clinically appear quite similar at baseline evaluation. We sought to investigate the use of kinematic assessment of postural instability (PI) using inertial measurement units (IMUs) as a mechanism of differentiation between the two disease processes. Methods: 20 patients with NPH, 55 patients with PD, and 56 age-matched, healthy controls underwent quantitative pull test examinations while wearing IMUs at baseline. Center of mass and foot position data were used to compare velocity and acceleration profiles, pull test step length, and reaction times between groups and as a function of Unified Parkinson's disease Rating Scale Pull Test (UPDRSPT) score. Results: Overall, the reactive postural response of NPH patients was characterized by slower reaction times and smaller steps compared to both PD patients and healthy controls. However, when patients were grouped by UPDRSPT scores, no reliable objective difference between groups was detected. Conclusion: At their initial evaluation, very few NPH patients demonstrate “normal” or “mild” PI as they appear to be older upon presentation compared to PD patients. As a result, kinematic assessment utilizing IMUs may not be helpful for differentiating between NPH and PD as a function of UPDRSPT score, but rather as a more fine-tuned method to define disease progression. We emphasize the need for further evaluation of incorporating objective kinematic data collection as a way to evaluate PI and improve patient outcomes. |
| first_indexed | 2024-03-07T16:23:10Z |
| format | Article |
| id | doaj.art-e8506ece781440d0bc96d216dc50754c |
| institution | Directory Open Access Journal |
| issn | 2590-1397 |
| language | English |
| last_indexed | 2024-03-07T16:23:10Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj.art-e8506ece781440d0bc96d216dc50754c2024-03-04T04:12:18ZengElsevierWorld Neurosurgery: X2590-13972024-04-0122100299Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's diseaseJacob T. Hanson0Luke T. Sabal1James N. Jean2Alec Jonason3Reid Johnson4Thomas Lisko5Yeng Moua6Robert A. McGovern7Rocky Vista University College of Osteopathic Medicine, Parker, CO, USA; University of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USA; The Ohio State University Department of Neurosurgery, Columbus, OH, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USAUniversity of Minnesota Department of Neurosurgery, Minneapolis, MN, USA; Division of Neurosurgery, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA; Corresponding author. University of Minnesota 420 Delaware St. SE MMC 96, Room D-429 Minneapolis, MN 55455, USA.Objective: Patients with normal pressure hydrocephalus (NPH) and Parkinson's Disease (PD) can clinically appear quite similar at baseline evaluation. We sought to investigate the use of kinematic assessment of postural instability (PI) using inertial measurement units (IMUs) as a mechanism of differentiation between the two disease processes. Methods: 20 patients with NPH, 55 patients with PD, and 56 age-matched, healthy controls underwent quantitative pull test examinations while wearing IMUs at baseline. Center of mass and foot position data were used to compare velocity and acceleration profiles, pull test step length, and reaction times between groups and as a function of Unified Parkinson's disease Rating Scale Pull Test (UPDRSPT) score. Results: Overall, the reactive postural response of NPH patients was characterized by slower reaction times and smaller steps compared to both PD patients and healthy controls. However, when patients were grouped by UPDRSPT scores, no reliable objective difference between groups was detected. Conclusion: At their initial evaluation, very few NPH patients demonstrate “normal” or “mild” PI as they appear to be older upon presentation compared to PD patients. As a result, kinematic assessment utilizing IMUs may not be helpful for differentiating between NPH and PD as a function of UPDRSPT score, but rather as a more fine-tuned method to define disease progression. We emphasize the need for further evaluation of incorporating objective kinematic data collection as a way to evaluate PI and improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2590139724000309Normal pressure hydrocephalusPostural instabilityKinematicsDiagnosisParkinson's disease |
| spellingShingle | Jacob T. Hanson Luke T. Sabal James N. Jean Alec Jonason Reid Johnson Thomas Lisko Yeng Moua Robert A. McGovern Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease World Neurosurgery: X Normal pressure hydrocephalus Postural instability Kinematics Diagnosis Parkinson's disease |
| title | Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease |
| title_full | Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease |
| title_fullStr | Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease |
| title_full_unstemmed | Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease |
| title_short | Utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and Parkinson's disease |
| title_sort | utilizing kinematic analysis of postural instability as an objective measure to aid in distinguishing between normal pressure hydrocephalus and parkinson s disease |
| topic | Normal pressure hydrocephalus Postural instability Kinematics Diagnosis Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724000309 |
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