Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to le...

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Bibliographic Details
Main Authors: Jun Liu, Lihui Wang, Zhiguo Wang, Jun-Ping Liu
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
telomere
ageing
lifespan
senescence
replicative ageing
chronological ageing
yeast
Online Access:http://www.mdpi.com/2073-4409/8/1/54

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