Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation
ObjectiveHolistic care is a key element in nursing care. Aiming at the heterogeneous disease of cerebral palsy, researchers focused on children with cerebral palsy who received transnasal transplantation of neural stem cells as a specific group. Based on establishing a multidisciplinary team, compre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1297563/full |
| _version_ | 1827390358876585984 |
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| author | Xiaoyan Li Xiaoyan Li Mengyao Li Xixian Qin Ying Li Ying Li Yachen Wang Yachen Wang Chao Han Chao Han Shiwei Ni Shiwei Ni Xuna Sun Peipei Dong Jing Liu Jing Liu |
| author_facet | Xiaoyan Li Xiaoyan Li Mengyao Li Xixian Qin Ying Li Ying Li Yachen Wang Yachen Wang Chao Han Chao Han Shiwei Ni Shiwei Ni Xuna Sun Peipei Dong Jing Liu Jing Liu |
| author_sort | Xiaoyan Li |
| collection | DOAJ |
| description | ObjectiveHolistic care is a key element in nursing care. Aiming at the heterogeneous disease of cerebral palsy, researchers focused on children with cerebral palsy who received transnasal transplantation of neural stem cells as a specific group. Based on establishing a multidisciplinary team, comprehensive care is carried out for this type of patient during the perioperative period to improve the effectiveness and safety of clinical research and increase the comfort of children.MethodsBetween January 2018 and June 2023, 22 children with cerebral palsy underwent three transnasal transplants of neural stem cells.ResultsNo adverse reactions related to immune rejection were observed in the 22 children during hospitalization and follow-up. All children tolerated the treatment well, and the treatment was superior. One child developed nausea and vomiting after sedation; three had a small amount of bleeding of nasal mucosa after transplantation. Two children had a low fever (≤38.5°C), and one had a change in the type and frequency of complex partial seizures. Moreover, 3 children experienced patch shedding within 4 h of patch implantation into the nasal cavity.ConclusionThe project team adopted nasal stem cell transplantation technology. Based on the characteristics of transnasal transplantation of neural stem cells in the treatment of neurological diseases in children, a comprehensive and novel holistic care plan is proposed. It is of great significance to guide caregivers of children to complete proper care, further improve the safety and effectiveness of treatment, and reduce the occurrence of complications. |
| first_indexed | 2024-03-08T16:51:30Z |
| format | Article |
| id | doaj.art-e85699fcc6d14c2ba086fa07a0d79c24 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T16:51:30Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-e85699fcc6d14c2ba086fa07a0d79c242024-01-05T04:39:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011110.3389/fped.2023.12975631297563Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantationXiaoyan Li0Xiaoyan Li1Mengyao Li2Xixian Qin3Ying Li4Ying Li5Yachen Wang6Yachen Wang7Chao Han8Chao Han9Shiwei Ni10Shiwei Ni11Xuna Sun12Peipei Dong13Jing Liu14Jing Liu15Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaStem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, ChinaDalian Innovation Institute of Stem Cell and Precision Medicine, Dalian, Liaoning Province, ChinaObjectiveHolistic care is a key element in nursing care. Aiming at the heterogeneous disease of cerebral palsy, researchers focused on children with cerebral palsy who received transnasal transplantation of neural stem cells as a specific group. Based on establishing a multidisciplinary team, comprehensive care is carried out for this type of patient during the perioperative period to improve the effectiveness and safety of clinical research and increase the comfort of children.MethodsBetween January 2018 and June 2023, 22 children with cerebral palsy underwent three transnasal transplants of neural stem cells.ResultsNo adverse reactions related to immune rejection were observed in the 22 children during hospitalization and follow-up. All children tolerated the treatment well, and the treatment was superior. One child developed nausea and vomiting after sedation; three had a small amount of bleeding of nasal mucosa after transplantation. Two children had a low fever (≤38.5°C), and one had a change in the type and frequency of complex partial seizures. Moreover, 3 children experienced patch shedding within 4 h of patch implantation into the nasal cavity.ConclusionThe project team adopted nasal stem cell transplantation technology. Based on the characteristics of transnasal transplantation of neural stem cells in the treatment of neurological diseases in children, a comprehensive and novel holistic care plan is proposed. It is of great significance to guide caregivers of children to complete proper care, further improve the safety and effectiveness of treatment, and reduce the occurrence of complications.https://www.frontiersin.org/articles/10.3389/fped.2023.1297563/fullneural stem cellscerebral palsyholistic careintranasal administrationpediatric nursing |
| spellingShingle | Xiaoyan Li Xiaoyan Li Mengyao Li Xixian Qin Ying Li Ying Li Yachen Wang Yachen Wang Chao Han Chao Han Shiwei Ni Shiwei Ni Xuna Sun Peipei Dong Jing Liu Jing Liu Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation Frontiers in Pediatrics neural stem cells cerebral palsy holistic care intranasal administration pediatric nursing |
| title | Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| title_full | Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| title_fullStr | Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| title_full_unstemmed | Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| title_short | Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| title_sort | providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation |
| topic | neural stem cells cerebral palsy holistic care intranasal administration pediatric nursing |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1297563/full |
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