A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan
A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/8/6778/ |
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| author | Xu-Hui Huang Wei Wang Wei Huo Qing-Qing Cheng Lu-Lu Hou Jian-Ping Zhou Qiang Zhang Xiao-Pan Wang Zhen-Hai Zhang Hui-Xia Lv |
| author_facet | Xu-Hui Huang Wei Wang Wei Huo Qing-Qing Cheng Lu-Lu Hou Jian-Ping Zhou Qiang Zhang Xiao-Pan Wang Zhen-Hai Zhang Hui-Xia Lv |
| author_sort | Xu-Hui Huang |
| collection | DOAJ |
| description | A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analysis estimated that the degrees of substitution (DS) of arginine in CS were 6%, 31.3% and 61.5%, respectively. The drug adefovir was chosen as model and its permeation flux across excised mice skin was investigated using a Franz diffusion cell. The results showed that the most effective enhancer was 2% (w/v) concentration of 10 kDa N-Arg-CS with 6% DS. At neutral pH, the cumulative amount of adefovir permeated after 12 hours was 2.63 ± 0.19 mg cm−2 which was 5.83-fold more than adefovir aqueous solution. Meanwhile N-Arg-CS was 1.83, 2.22, and 2.45 times more effective than Azone, eucalyptus and peppermint, respectively. The obtained results suggest that N-Arg-CS could be a promising transdermal enhancer. |
| first_indexed | 2024-12-21T17:29:36Z |
| format | Article |
| id | doaj.art-e858580172c44e9891c6f6713f320772 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T17:29:36Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e858580172c44e9891c6f6713f3207722022-12-21T18:55:57ZengMDPI AGMolecules1420-30492011-08-011686778679010.3390/molecules16086778A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine ChitosanXu-Hui HuangWei WangWei HuoQing-Qing ChengLu-Lu HouJian-Ping ZhouQiang ZhangXiao-Pan WangZhen-Hai ZhangHui-Xia LvA novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analysis estimated that the degrees of substitution (DS) of arginine in CS were 6%, 31.3% and 61.5%, respectively. The drug adefovir was chosen as model and its permeation flux across excised mice skin was investigated using a Franz diffusion cell. The results showed that the most effective enhancer was 2% (w/v) concentration of 10 kDa N-Arg-CS with 6% DS. At neutral pH, the cumulative amount of adefovir permeated after 12 hours was 2.63 ± 0.19 mg cm−2 which was 5.83-fold more than adefovir aqueous solution. Meanwhile N-Arg-CS was 1.83, 2.22, and 2.45 times more effective than Azone, eucalyptus and peppermint, respectively. The obtained results suggest that N-Arg-CS could be a promising transdermal enhancer.http://www.mdpi.com/1420-3049/16/8/6778/biomimetic chitosan derivatesarginine-richcell penetration peptidesN-arginine chitosantransdermal enhanceradefovir |
| spellingShingle | Xu-Hui Huang Wei Wang Wei Huo Qing-Qing Cheng Lu-Lu Hou Jian-Ping Zhou Qiang Zhang Xiao-Pan Wang Zhen-Hai Zhang Hui-Xia Lv A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan Molecules biomimetic chitosan derivates arginine-rich cell penetration peptides N-arginine chitosan transdermal enhancer adefovir |
| title | A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan |
| title_full | A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan |
| title_fullStr | A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan |
| title_full_unstemmed | A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan |
| title_short | A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan |
| title_sort | biomimetic chitosan derivates preparation characterization and transdermal enhancement studies of n arginine chitosan |
| topic | biomimetic chitosan derivates arginine-rich cell penetration peptides N-arginine chitosan transdermal enhancer adefovir |
| url | http://www.mdpi.com/1420-3049/16/8/6778/ |
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