Olmesartan-induced enteropathy
The association between sprue-like enteropathy and olmesartan is described in recent literature and is an entity that manifests with chronic diarrhea and should be considered in its differential diagnosis. Olmesartan is a commonly used antihypertensive and the recognition of this entity may reduce t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2023-01-01
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| Series: | Medicina Clínica Práctica |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2603924922000301 |
| _version_ | 1797948280591613952 |
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| author | Sofia Moura de Azevedo Diana Isabel Rocha Daniela Neto Manuela Vidigal Bertão |
| author_facet | Sofia Moura de Azevedo Diana Isabel Rocha Daniela Neto Manuela Vidigal Bertão |
| author_sort | Sofia Moura de Azevedo |
| collection | DOAJ |
| description | The association between sprue-like enteropathy and olmesartan is described in recent literature and is an entity that manifests with chronic diarrhea and should be considered in its differential diagnosis. Olmesartan is a commonly used antihypertensive and the recognition of this entity may reduce the overuse of expensive complementary means of diagnosis. We present 2 cases of chronic diarrhea without blood, one with severe metabolic acidemia that motivated intensive care and renal replacement therapy. No evidence of infection, negative stool cultures, anti-transglutaminase was negative. In both cases, there were no macroscopy alterations, and biopsy was performed in one of the cases. It was considered olmesartan-associated enteropathy, and with its suspension, the clinic did not recur. Being a reversible side effect of a common drug, we should consider their suspension before initiating an extensive investigation of chronic diarrhea. Resumen: La asociación entre la enteropatía tipo esprue y el olmesartán está descrita en la literatura reciente y es una entidad que se manifiesta con diarrea crónica y debe ser considerada en su diagnóstico diferencial. El olmesartán es un antihipertensivo de uso común y el reconocimiento de esta entidad puede reducir el uso excesivo de medios complementarios costosos de diagnóstico. Presentamos dos casos de diarrea crónica, uno de ellos con acidemia metabólica grave que motivó cuidados intensivos y terapia renal sustitutiva. No había evidencia de infección, los coprocultivos fueron negativos y la antitransglutaminasa fue negativa. En ambos casos no había alteraciones macroscópicas y en uno de ellos se realizó biopsia. Se consideró enteropatía asociada a olmesartán, y con su suspensión, la clínica no recurrió. Al ser un efecto secundario reversible de un fármaco común, debemos considerar su suspensión antes de iniciar una investigación exhaustiva de la diarrea crónica. |
| first_indexed | 2024-04-10T21:40:50Z |
| format | Article |
| id | doaj.art-e85e50ba426f427a88ce6a925048b228 |
| institution | Directory Open Access Journal |
| issn | 2603-9249 |
| language | English |
| last_indexed | 2024-04-10T21:40:50Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Medicina Clínica Práctica |
| spelling | doaj.art-e85e50ba426f427a88ce6a925048b2282023-01-19T04:17:35ZengElsevier EspañaMedicina Clínica Práctica2603-92492023-01-0161100348Olmesartan-induced enteropathySofia Moura de Azevedo0Diana Isabel Rocha1Daniela Neto2Manuela Vidigal Bertão3Internal Medicine, Porto University Hospital, Largo Professor Abel Salazar, 2, 4099-003 Porto, Portugal; Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Largo Professor Abel Salazar, 2, 4099-003 Porto, Portugal; Corresponding author.Internal Medicine, Porto University Hospital, Largo Professor Abel Salazar, 2, 4099-003 Porto, PortugalInternal Medicine, Senhora da Oliveira Hospital, Guimarães, PortugalInternal Medicine, Porto University Hospital, Largo Professor Abel Salazar, 2, 4099-003 Porto, PortugalThe association between sprue-like enteropathy and olmesartan is described in recent literature and is an entity that manifests with chronic diarrhea and should be considered in its differential diagnosis. Olmesartan is a commonly used antihypertensive and the recognition of this entity may reduce the overuse of expensive complementary means of diagnosis. We present 2 cases of chronic diarrhea without blood, one with severe metabolic acidemia that motivated intensive care and renal replacement therapy. No evidence of infection, negative stool cultures, anti-transglutaminase was negative. In both cases, there were no macroscopy alterations, and biopsy was performed in one of the cases. It was considered olmesartan-associated enteropathy, and with its suspension, the clinic did not recur. Being a reversible side effect of a common drug, we should consider their suspension before initiating an extensive investigation of chronic diarrhea. Resumen: La asociación entre la enteropatía tipo esprue y el olmesartán está descrita en la literatura reciente y es una entidad que se manifiesta con diarrea crónica y debe ser considerada en su diagnóstico diferencial. El olmesartán es un antihipertensivo de uso común y el reconocimiento de esta entidad puede reducir el uso excesivo de medios complementarios costosos de diagnóstico. Presentamos dos casos de diarrea crónica, uno de ellos con acidemia metabólica grave que motivó cuidados intensivos y terapia renal sustitutiva. No había evidencia de infección, los coprocultivos fueron negativos y la antitransglutaminasa fue negativa. En ambos casos no había alteraciones macroscópicas y en uno de ellos se realizó biopsia. Se consideró enteropatía asociada a olmesartán, y con su suspensión, la clínica no recurrió. Al ser un efecto secundario reversible de un fármaco común, debemos considerar su suspensión antes de iniciar una investigación exhaustiva de la diarrea crónica.http://www.sciencedirect.com/science/article/pii/S2603924922000301enteropatía tipo esprueenteropatía inducida por olmesartánolmesartándiarrea crónicaenteropatía |
| spellingShingle | Sofia Moura de Azevedo Diana Isabel Rocha Daniela Neto Manuela Vidigal Bertão Olmesartan-induced enteropathy Medicina Clínica Práctica enteropatía tipo esprue enteropatía inducida por olmesartán olmesartán diarrea crónica enteropatía |
| title | Olmesartan-induced enteropathy |
| title_full | Olmesartan-induced enteropathy |
| title_fullStr | Olmesartan-induced enteropathy |
| title_full_unstemmed | Olmesartan-induced enteropathy |
| title_short | Olmesartan-induced enteropathy |
| title_sort | olmesartan induced enteropathy |
| topic | enteropatía tipo esprue enteropatía inducida por olmesartán olmesartán diarrea crónica enteropatía |
| url | http://www.sciencedirect.com/science/article/pii/S2603924922000301 |
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