Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies
<b>(1) Background and Objectives:</b> Dark-blood late gadolinium enhancement has been shown to be a reliable cardiac magnetic resonance (CMR) method for assessing viability and depicting myocardial scarring in ischemic cardiomyopathy. The aim of this study was to evaluate dark-blood LGE...
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/9/1634 |
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| author | Jan M. Brendel Robert J. Holtackers Jan N. Geisel Jens Kübler Florian Hagen Meinrad Gawaz Konstantin Nikolaou Simon Greulich Patrick Krumm |
| author_facet | Jan M. Brendel Robert J. Holtackers Jan N. Geisel Jens Kübler Florian Hagen Meinrad Gawaz Konstantin Nikolaou Simon Greulich Patrick Krumm |
| author_sort | Jan M. Brendel |
| collection | DOAJ |
| description | <b>(1) Background and Objectives:</b> Dark-blood late gadolinium enhancement has been shown to be a reliable cardiac magnetic resonance (CMR) method for assessing viability and depicting myocardial scarring in ischemic cardiomyopathy. The aim of this study was to evaluate dark-blood LGE imaging compared with conventional bright-blood LGE for the detection of myocardial scarring in non-ischemic cardiomyopathies. <b>(2) Materials and Methods:</b> Patients with suspected non-ischemic cardiomyopathy were prospectively enrolled in this single-centre study from January 2020 to March 2023. All patients underwent 1.5 T CMR with both dark-blood and conventional bright-blood LGE imaging. Corresponding short-axis stacks of both techniques were analysed for the presence, distribution, pattern, and localisation of LGE, as well as the quantitative scar size (%). <b>(3) Results:</b> 343 patients (age 44 ± 17 years; 124 women) with suspected non-ischemic cardiomyopathy were examined. LGE was detected in 123 of 343 cases (36%) with excellent inter-reader agreement (κ 0.97–0.99) for both LGE techniques. Dark-blood LGE showed a sensitivity of 99% (CI 98–100), specificity of 99% (CI 98–100), and an accuracy of 99% (CI 99–100) for the detection of non-ischemic scarring. No significant difference in total scar size (%) was observed. Dark-blood imaging with mean 5.35 ± 4.32% enhanced volume of total myocardial volume, bright-blood with 5.24 ± 4.28%, <i>p</i> = 0.84. <b>(4) Conclusions:</b> Dark-blood LGE imaging is non-inferior to conventional bright-blood LGE imaging in detecting non-ischemic scarring. Therefore, dark-blood LGE imaging may become an equivalent method for the detection of both ischemic and non-ischemic scars. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T04:21:39Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e85e569df6a24fe685dc027d595d523c2023-11-17T22:46:22ZengMDPI AGDiagnostics2075-44182023-05-01139163410.3390/diagnostics13091634Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic CardiomyopathiesJan M. Brendel0Robert J. Holtackers1Jan N. Geisel2Jens Kübler3Florian Hagen4Meinrad Gawaz5Konstantin Nikolaou6Simon Greulich7Patrick Krumm8Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre, 6229 HX Maastricht, The NetherlandsDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Internal Medicine III, Cardiology and Angiology, University of Tübingen Otfried-Müller-Straße 10, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Internal Medicine III, Cardiology and Angiology, University of Tübingen Otfried-Müller-Straße 10, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany<b>(1) Background and Objectives:</b> Dark-blood late gadolinium enhancement has been shown to be a reliable cardiac magnetic resonance (CMR) method for assessing viability and depicting myocardial scarring in ischemic cardiomyopathy. The aim of this study was to evaluate dark-blood LGE imaging compared with conventional bright-blood LGE for the detection of myocardial scarring in non-ischemic cardiomyopathies. <b>(2) Materials and Methods:</b> Patients with suspected non-ischemic cardiomyopathy were prospectively enrolled in this single-centre study from January 2020 to March 2023. All patients underwent 1.5 T CMR with both dark-blood and conventional bright-blood LGE imaging. Corresponding short-axis stacks of both techniques were analysed for the presence, distribution, pattern, and localisation of LGE, as well as the quantitative scar size (%). <b>(3) Results:</b> 343 patients (age 44 ± 17 years; 124 women) with suspected non-ischemic cardiomyopathy were examined. LGE was detected in 123 of 343 cases (36%) with excellent inter-reader agreement (κ 0.97–0.99) for both LGE techniques. Dark-blood LGE showed a sensitivity of 99% (CI 98–100), specificity of 99% (CI 98–100), and an accuracy of 99% (CI 99–100) for the detection of non-ischemic scarring. No significant difference in total scar size (%) was observed. Dark-blood imaging with mean 5.35 ± 4.32% enhanced volume of total myocardial volume, bright-blood with 5.24 ± 4.28%, <i>p</i> = 0.84. <b>(4) Conclusions:</b> Dark-blood LGE imaging is non-inferior to conventional bright-blood LGE imaging in detecting non-ischemic scarring. Therefore, dark-blood LGE imaging may become an equivalent method for the detection of both ischemic and non-ischemic scars.https://www.mdpi.com/2075-4418/13/9/1634magnetic resonance imagingheartcontrast mediagadoliniumLGEcardiomyopathies |
| spellingShingle | Jan M. Brendel Robert J. Holtackers Jan N. Geisel Jens Kübler Florian Hagen Meinrad Gawaz Konstantin Nikolaou Simon Greulich Patrick Krumm Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies Diagnostics magnetic resonance imaging heart contrast media gadolinium LGE cardiomyopathies |
| title | Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies |
| title_full | Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies |
| title_fullStr | Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies |
| title_full_unstemmed | Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies |
| title_short | Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies |
| title_sort | dark blood late gadolinium enhancement mri is noninferior to bright blood lge in non ischemic cardiomyopathies |
| topic | magnetic resonance imaging heart contrast media gadolinium LGE cardiomyopathies |
| url | https://www.mdpi.com/2075-4418/13/9/1634 |
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