Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis
Background: Patients with eosinophilic chronic rhinosinusitis (ECRS) respond poorly to many treatment modalities. Overproduction of periostin in the nasal mucosa is reported to contribute to polyp formation. This study examined periostin levels in patients with ECRS in comparison with levels in pati...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893022000934 |
| _version_ | 1797946399091851264 |
|---|---|
| author | Teruyuki Sato Hiroki Ikeda Keigo Murakami Kazuhiro Murakami Shion Shirane Nobuo Ohta |
| author_facet | Teruyuki Sato Hiroki Ikeda Keigo Murakami Kazuhiro Murakami Shion Shirane Nobuo Ohta |
| author_sort | Teruyuki Sato |
| collection | DOAJ |
| description | Background: Patients with eosinophilic chronic rhinosinusitis (ECRS) respond poorly to many treatment modalities. Overproduction of periostin in the nasal mucosa is reported to contribute to polyp formation. This study examined periostin levels in patients with ECRS in comparison with levels in patients with non-ECRS. Methods: Fifty-nine patients with chronic rhinosinusitis were grouped into those with ECRS and those with non-ECRS. We compared the relationships between peripheral blood eosinophil level, serum periostin level, histopathological findings, clinical and laboratory findings, nose findings, diagnostic score of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study, and postoperative recurrence of nasal polyps in each group. Results: In the ECRS group, a positive correlation was found between peripheral blood eosinophil level and serum periostin level (rs = 0.49, P < 0.01: Spearman's rank correlation coefficient). ROC curve analysis was used to evaluate the serum periostin level that could predict postoperative recurrence of nasal polyps in the ECRS group: the area under the curve (AUC) was 0.95, sensitivity was 92%, and specificity was 100%; the serum periostin cutoff value for postoperative recurrence of nasal polyps was 130 ng/ml. In ROC curve analysis to evaluate peripheral blood eosinophil level, the AUC was 0.73, sensitivity was 69.2%, and specificity was 85.0%; the cutoff value was 8.8%. Conclusions: periostin was implicated in the pathophysiology of ECRS. Periostin shown to be a more useful biomarker than eosinophils in ECRS. Periostin was shown to likely be an important biomarker for pathological severity of ECRS and postoperative recurrence of nasal polyps. |
| first_indexed | 2024-04-10T21:10:25Z |
| format | Article |
| id | doaj.art-e85ee98eb54b4406991a3a611898c245 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-10T21:10:25Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-e85ee98eb54b4406991a3a611898c2452023-01-21T04:20:23ZengElsevierAllergology International1323-89302023-01-01721161168Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitisTeruyuki Sato0Hiroki Ikeda1Keigo Murakami2Kazuhiro Murakami3Shion Shirane4Nobuo Ohta5Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai, Japan; Corresponding author. Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai 983-8536, Japan.Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center, Wakayama, JapanDivision of Pathology, Tohoku Medical and Pharmaceutical University, Sendai, JapanDivision of Pathology, Tohoku Medical and Pharmaceutical University, Sendai, JapanDivision of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai, JapanDivision of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai, JapanBackground: Patients with eosinophilic chronic rhinosinusitis (ECRS) respond poorly to many treatment modalities. Overproduction of periostin in the nasal mucosa is reported to contribute to polyp formation. This study examined periostin levels in patients with ECRS in comparison with levels in patients with non-ECRS. Methods: Fifty-nine patients with chronic rhinosinusitis were grouped into those with ECRS and those with non-ECRS. We compared the relationships between peripheral blood eosinophil level, serum periostin level, histopathological findings, clinical and laboratory findings, nose findings, diagnostic score of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study, and postoperative recurrence of nasal polyps in each group. Results: In the ECRS group, a positive correlation was found between peripheral blood eosinophil level and serum periostin level (rs = 0.49, P < 0.01: Spearman's rank correlation coefficient). ROC curve analysis was used to evaluate the serum periostin level that could predict postoperative recurrence of nasal polyps in the ECRS group: the area under the curve (AUC) was 0.95, sensitivity was 92%, and specificity was 100%; the serum periostin cutoff value for postoperative recurrence of nasal polyps was 130 ng/ml. In ROC curve analysis to evaluate peripheral blood eosinophil level, the AUC was 0.73, sensitivity was 69.2%, and specificity was 85.0%; the cutoff value was 8.8%. Conclusions: periostin was implicated in the pathophysiology of ECRS. Periostin shown to be a more useful biomarker than eosinophils in ECRS. Periostin was shown to likely be an important biomarker for pathological severity of ECRS and postoperative recurrence of nasal polyps.http://www.sciencedirect.com/science/article/pii/S1323893022000934BiomarkerChronic sinusitisEosinophilsHuman nasal epithelial cellsNasal polyps |
| spellingShingle | Teruyuki Sato Hiroki Ikeda Keigo Murakami Kazuhiro Murakami Shion Shirane Nobuo Ohta Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis Allergology International Biomarker Chronic sinusitis Eosinophils Human nasal epithelial cells Nasal polyps |
| title | Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| title_full | Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| title_fullStr | Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| title_full_unstemmed | Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| title_short | Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| title_sort | periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis |
| topic | Biomarker Chronic sinusitis Eosinophils Human nasal epithelial cells Nasal polyps |
| url | http://www.sciencedirect.com/science/article/pii/S1323893022000934 |
| work_keys_str_mv | AT teruyukisato periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis AT hirokiikeda periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis AT keigomurakami periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis AT kazuhiromurakami periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis AT shionshirane periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis AT nobuoohta periostinisanaggravatingfactorandpredictivebiomarkerofeosinophilicchronicrhinosinusitis |