Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity
<p>Abstract</p> <p>Background</p> <p>Having considered how bioavailable aluminium (Al) may affect ecological systems and animals living there, especially cattle, and in search for a preventive dietary treatment against Al toxicity, we aimed to test the protective role o...
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://www.biomedcentral.com/1746-6148/9/22 |
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| author | Belaïd-Nouira Yosra Bakhta Hayfa Haouas Zohra Flehi-Slim Imen Neffati Fadoua Najjar Mohamed Fadhel Cheikh Hassen Ben |
| author_facet | Belaïd-Nouira Yosra Bakhta Hayfa Haouas Zohra Flehi-Slim Imen Neffati Fadoua Najjar Mohamed Fadhel Cheikh Hassen Ben |
| author_sort | Belaïd-Nouira Yosra |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Having considered how bioavailable aluminium (Al) may affect ecological systems and animals living there, especially cattle, and in search for a preventive dietary treatment against Al toxicity, we aimed to test the protective role of fenugreek seeds against chronic liver injury induced by aluminum chloride (AlCl<sub>3</sub>) in Wistar rats.</p> <p>Results</p> <p>Five months of AlCl<sub>3</sub> oral exposure (500 mg/kg bw i.g for one month then 1600 ppm via drinking water) caused liver atrophy, an inhibition of aspartate transaminase (AST), alanine transaminase (ALT) and glutamyl transpeptidase (GGT), an enhancement of both lipid peroxidation and lactate dehydrogenase (LDH) activity and an increase of total protein level in liver. Moreover, histopathological and histochemical examinations revealed moderate alterations in the hepatic parenchyma in addition to a disrupted iron metabolism. Co-administration of fenugreek seed powder (FSP) at 5% in pellet diet during two months succeeded to antagonize the harmful effects of AlCl<sub>3</sub> by restoring all tested parameters.</p> <p>Conclusion</p> <p>This study highlighted the hepatotoxicity of AlCl<sub>3</sub> through biochemical and histological parameters in one hand and the hepatoprotective role of fenugreek seeds on the other hand. Thus this work could be a pilot study which will encourage farmers to use fenugreek seeds as a detoxifying diet supplement for domestic animals.</p> |
| first_indexed | 2024-12-10T16:53:52Z |
| format | Article |
| id | doaj.art-e85f578328974ce3afda5d87a982629f |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-10T16:53:52Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-e85f578328974ce3afda5d87a982629f2022-12-22T01:40:49ZengBMCBMC Veterinary Research1746-61482013-01-01912210.1186/1746-6148-9-22Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicityBelaïd-Nouira YosraBakhta HayfaHaouas ZohraFlehi-Slim ImenNeffati FadouaNajjar Mohamed FadhelCheikh Hassen Ben<p>Abstract</p> <p>Background</p> <p>Having considered how bioavailable aluminium (Al) may affect ecological systems and animals living there, especially cattle, and in search for a preventive dietary treatment against Al toxicity, we aimed to test the protective role of fenugreek seeds against chronic liver injury induced by aluminum chloride (AlCl<sub>3</sub>) in Wistar rats.</p> <p>Results</p> <p>Five months of AlCl<sub>3</sub> oral exposure (500 mg/kg bw i.g for one month then 1600 ppm via drinking water) caused liver atrophy, an inhibition of aspartate transaminase (AST), alanine transaminase (ALT) and glutamyl transpeptidase (GGT), an enhancement of both lipid peroxidation and lactate dehydrogenase (LDH) activity and an increase of total protein level in liver. Moreover, histopathological and histochemical examinations revealed moderate alterations in the hepatic parenchyma in addition to a disrupted iron metabolism. Co-administration of fenugreek seed powder (FSP) at 5% in pellet diet during two months succeeded to antagonize the harmful effects of AlCl<sub>3</sub> by restoring all tested parameters.</p> <p>Conclusion</p> <p>This study highlighted the hepatotoxicity of AlCl<sub>3</sub> through biochemical and histological parameters in one hand and the hepatoprotective role of fenugreek seeds on the other hand. Thus this work could be a pilot study which will encourage farmers to use fenugreek seeds as a detoxifying diet supplement for domestic animals.</p>http://www.biomedcentral.com/1746-6148/9/22AlCl<sub><b>3</b></sub>LiverTrigonella foenum-graecumLipid peroxidationHistopathologyIron metabolism |
| spellingShingle | Belaïd-Nouira Yosra Bakhta Hayfa Haouas Zohra Flehi-Slim Imen Neffati Fadoua Najjar Mohamed Fadhel Cheikh Hassen Ben Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity BMC Veterinary Research AlCl<sub><b>3</b></sub> Liver Trigonella foenum-graecum Lipid peroxidation Histopathology Iron metabolism |
| title | Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity |
| title_full | Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity |
| title_fullStr | Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity |
| title_full_unstemmed | Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity |
| title_short | Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl<sub>3</sub> toxicity |
| title_sort | fenugreek seeds a hepatoprotector forage crop against chronic alcl sub 3 sub toxicity |
| topic | AlCl<sub><b>3</b></sub> Liver Trigonella foenum-graecum Lipid peroxidation Histopathology Iron metabolism |
| url | http://www.biomedcentral.com/1746-6148/9/22 |
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