Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review

Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several...

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Main Authors: Reza Karbasi Afshar, Nematollah Jafari Joneidi, Reza Imani, Mozhgan Fazel
Format: Article
Language:English
Published: International Travel Medicine Center of Iran 2013-09-01
Series:International Journal of Travel Medicine and Global Health
Subjects:
Online Access:http://www.ijtmgh.com/article_33333_6329fc5b88bd1cb6bb512d06ab5ddc76.pdf
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author Reza Karbasi Afshar
Nematollah Jafari Joneidi
Reza Imani
Mozhgan Fazel
author_facet Reza Karbasi Afshar
Nematollah Jafari Joneidi
Reza Imani
Mozhgan Fazel
author_sort Reza Karbasi Afshar
collection DOAJ
description Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been issued. Most studies indicated increased prevalence, incidence and mortality rates for CMP in the HIV infected patients, especially in more advanced grades of the infection. CD4 cell count has been shown to be associated with both incidence and outcome of HIV-related CMP. In children, also similar findings have been observed with high incidence and mortality rates associated with CMP-HIV have been observed. However, prepartum CMP burden in HIV infected mothers was not different than that in HIV-negative ones. However, evidence about the effects of ART on the development and progression of HIV-related CMP was very controversial. While is some studies, no associations have been found in some others, ART has been associated with either a better or worse disease incidence or condition. We propose more studies with prospective approach and large patient populations to be conducted for better understanding of the effects of different ART agents on the incidence and outcome of HIV-related CMP.
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spelling doaj.art-e85f774944df44bd9de2f9c1d2aeaee12022-12-21T16:58:39ZengInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-11002476-57592013-09-0111758833333Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic ReviewReza Karbasi Afshar0Nematollah Jafari Joneidi1Reza Imani2Mozhgan Fazel3Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranHealth Research Center, Baqiyatallah University of Medical sciences, Tehran, IranShahrkord University of Medical Sciences, Shahrkord, IranHealth Research Center, Baqiyatallah University of Medical sciences, Tehran, Iran|International Teravel Medicine of Iran, Baqiyatallah, Tehran, IranHuman immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been issued. Most studies indicated increased prevalence, incidence and mortality rates for CMP in the HIV infected patients, especially in more advanced grades of the infection. CD4 cell count has been shown to be associated with both incidence and outcome of HIV-related CMP. In children, also similar findings have been observed with high incidence and mortality rates associated with CMP-HIV have been observed. However, prepartum CMP burden in HIV infected mothers was not different than that in HIV-negative ones. However, evidence about the effects of ART on the development and progression of HIV-related CMP was very controversial. While is some studies, no associations have been found in some others, ART has been associated with either a better or worse disease incidence or condition. We propose more studies with prospective approach and large patient populations to be conducted for better understanding of the effects of different ART agents on the incidence and outcome of HIV-related CMP.http://www.ijtmgh.com/article_33333_6329fc5b88bd1cb6bb512d06ab5ddc76.pdfHuman Immunodeficiency VirusHIVCardiomyopathyCardiac Dysfunctionrisk factor
spellingShingle Reza Karbasi Afshar
Nematollah Jafari Joneidi
Reza Imani
Mozhgan Fazel
Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
International Journal of Travel Medicine and Global Health
Human Immunodeficiency Virus
HIV
Cardiomyopathy
Cardiac Dysfunction
risk factor
title Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
title_full Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
title_fullStr Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
title_full_unstemmed Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
title_short Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
title_sort human immunodeficiency virus hiv and cardiomyopathy a systematic review
topic Human Immunodeficiency Virus
HIV
Cardiomyopathy
Cardiac Dysfunction
risk factor
url http://www.ijtmgh.com/article_33333_6329fc5b88bd1cb6bb512d06ab5ddc76.pdf
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AT rezaimani humanimmunodeficiencyvirushivandcardiomyopathyasystematicreview
AT mozhganfazel humanimmunodeficiencyvirushivandcardiomyopathyasystematicreview