Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii

Abstract Background Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis. Cysteine biosynthesis and the L-serine metabolic pathway play important roles in the energy metabolism of Acanthamoeba spp. H...

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Bibliographic Details
Main Authors: Duo Wu, Meng Feng, Zhi-xin Wang, Ke Qiao, Hiroshi Tachibana, Xun-jia Cheng
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Parasites & Vectors
Subjects:
Cysteine synthase
Cysteine biosynthesis
Glycerate dehydrogenase
Glycolysis pathway
Drug target
Online Access:http://link.springer.com/article/10.1186/s13071-018-3188-7

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