DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet

DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet

Dehydroepiandrosterone (DHEA) and the dehydroepiandrosterone sulfate (DHEA-S) are steroids produced mainly by the adrenal cortex. There is evidence from both human and animal models suggesting beneficial effects of these steroids for obesity, diabetes mellitus, hypertension, and osteoporosis, condit...

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Bibliographic Details
Main Authors: Katherine Veras, Felipe Natali Almeida, Renato Tadeu Nachbar, Daniel Simões de Jesus, João Paulo Camporez, Ângelo Rafael Carpinelli, Julia H. Goedecke, Carla Roberta de Oliveira Carvalho
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
High fat diet
Menopause
Pancreatic islets
Insulin sensitivity
Insulin secretion
p-Akt/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000060

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