Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome
OBJECTIVE: To evaluate eff ects of metformin on menstrual cyclicity in women with polycystic ovary syndrome. STUDY DESIGN: The study was designed as pre-, post prospective clinical trial. To enter the study, patients had to have well-documented PCOS, be oligo-(six cycles or less in the preceding yea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Network
2006-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/582 |
| _version_ | 1797920398029881344 |
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| author | Ülkü Bayar Görkem Mungan Mustafa Başaran Sibel Kıran Volkan Akbulut Murat Can |
| author_facet | Ülkü Bayar Görkem Mungan Mustafa Başaran Sibel Kıran Volkan Akbulut Murat Can |
| author_sort | Ülkü Bayar |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate eff ects of metformin on menstrual cyclicity in women with polycystic ovary syndrome.
STUDY DESIGN: The study was designed as pre-, post prospective clinical trial. To enter the study, patients had to have well-documented PCOS, be oligo-(six cycles or less in the preceding year) or amenorrheic (absence of menstrual cycles for 1 year), and not have exclusionary diseases or drugs. Metformin 500 mg orally twice daily was administered for 6 months. Serum fasting insulin, glucose, FSH, LH, estradiol, progesterone, prolactin, free testosterone, DHEAS, total cholesterol, triglyceride, AST, ALT, HDL, LDL, VLDL were measured. Quantitative insulin sensitivity check index (QUICKI) was used to measure the insulin resistance. Blood samples were collected at the initiation of therapy and 6 months after. Follow-up 6 months was scheduled with interval history, review of menstrual status, assessment of any metformin-related side effects, brief physical and laboratory examination.
RESULTS: Total 13/23(39.1%) of the patients with metformin treatment resumed normal menses 6 months after. Nine of 19 oligomenoreic women (47.4%) resumed regular normal menses; 4 of 4 (100%) amenoreic women resumed oligomenoric menses. The fasting blood glucose, fasting blood insulin, free testesteron, VLDL levels were decreased after 6 months of treatment (p=0.005; p= 0.002; p= 0.008; p=0.006 respectively ). First and sixth months measurements of QUICKI were found
significantly different (p=0.000).
CONCLUSION: Metformin therapy is well tolerated by the majority of patients and may be clinically useful, in nonobese patients with PCOS and menstrual disturbances. |
| first_indexed | 2024-04-10T14:00:33Z |
| format | Article |
| id | doaj.art-e85fe4ae1f114bddac5bc493dc66ecc4 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:00:33Z |
| publishDate | 2006-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-e85fe4ae1f114bddac5bc493dc66ecc42023-02-15T16:10:17ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512006-08-01122516Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary SyndromeÜlkü Bayar0Görkem Mungan1Mustafa Başaran2Sibel Kıran3Volkan Akbulut4Murat Can5Department of Obstetrics and Gynecology, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakDepartment of Biochemistry, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakDepartment of Obstetrics and Gynecology, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakDepartment of Biochemistry, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakDepartment of Obstetrics and Gynecology, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakDepartment of Biochemistry, Zonguldak Karaelmas University Faculty of Medicine, ZonguldakOBJECTIVE: To evaluate eff ects of metformin on menstrual cyclicity in women with polycystic ovary syndrome. STUDY DESIGN: The study was designed as pre-, post prospective clinical trial. To enter the study, patients had to have well-documented PCOS, be oligo-(six cycles or less in the preceding year) or amenorrheic (absence of menstrual cycles for 1 year), and not have exclusionary diseases or drugs. Metformin 500 mg orally twice daily was administered for 6 months. Serum fasting insulin, glucose, FSH, LH, estradiol, progesterone, prolactin, free testosterone, DHEAS, total cholesterol, triglyceride, AST, ALT, HDL, LDL, VLDL were measured. Quantitative insulin sensitivity check index (QUICKI) was used to measure the insulin resistance. Blood samples were collected at the initiation of therapy and 6 months after. Follow-up 6 months was scheduled with interval history, review of menstrual status, assessment of any metformin-related side effects, brief physical and laboratory examination. RESULTS: Total 13/23(39.1%) of the patients with metformin treatment resumed normal menses 6 months after. Nine of 19 oligomenoreic women (47.4%) resumed regular normal menses; 4 of 4 (100%) amenoreic women resumed oligomenoric menses. The fasting blood glucose, fasting blood insulin, free testesteron, VLDL levels were decreased after 6 months of treatment (p=0.005; p= 0.002; p= 0.008; p=0.006 respectively ). First and sixth months measurements of QUICKI were found significantly different (p=0.000). CONCLUSION: Metformin therapy is well tolerated by the majority of patients and may be clinically useful, in nonobese patients with PCOS and menstrual disturbances.http://gorm.com.tr/index.php/GORM/article/view/582PCOS, Metformin, Insulin resistance, Menstrual cycles |
| spellingShingle | Ülkü Bayar Görkem Mungan Mustafa Başaran Sibel Kıran Volkan Akbulut Murat Can Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome Gynecology Obstetrics & Reproductive Medicine PCOS, Metformin, Insulin resistance, Menstrual cycles |
| title | Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome |
| title_full | Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome |
| title_fullStr | Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome |
| title_short | Effects of Metformin on Menstrual Cyclicity in Women with Polycystic Ovary Syndrome |
| title_sort | effects of metformin on menstrual cyclicity in women with polycystic ovary syndrome |
| topic | PCOS, Metformin, Insulin resistance, Menstrual cycles |
| url | http://gorm.com.tr/index.php/GORM/article/view/582 |
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