Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension

Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension

Background: In 2012, mutations in Cav1 were found to be the driving mutation in several cases of heritable pulmonary arterial hypertension (PAH). These mutations replaced the last 21 amino acids of Cav1 with a novel 22-amino-acid sequence. Because previously only Cav1 knockouts had been studied in t...

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Bibliographic Details
Main Authors: Anandharajan Rathinasabapathy, Courtney Copeland, Amber Crabtree, Erica J. Carrier, Christy Moore, Sheila Shay, Santhi Gladson, Eric D. Austin, Anne K. Kenworthy, James E. Loyd, Anna R. Hemnes, James D. West
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Medicine
Subjects:
Cav1
pulmonary hypertension
exercise
inflammation
monocyte
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00540/full

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