Targeting Wnt/β-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer

Targeting Wnt/β-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer

Metastasis is the main cause of death for patients suffering gastric cancer. Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critical attributes of metastasis, both of which are regulated tightly by DNA methylation and Wnt/β-catenin signaling. Here, we studied the functions o...

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Bibliographic Details
Main Authors: Jingjing Qi, Di Cui, Qi-Nian Wu, Qi Zhao, Zhan-Hong Chen, Lianjie Li, Walter Birchmeier, Yong Yu, Ran Tao
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
gastric cancer
TET1
FOXO4
Wnt signaling
cancer stem cell
metastasis
Online Access:https://www.mdpi.com/2072-6694/14/13/3232

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