Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish
Abstract Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13041-020-00614-4 |
| _version_ | 1818923166177689600 |
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| author | Shiho Suzuki Ryo Kimura Shingo Maegawa Masatoshi Nakata Masatoshi Hagiwara |
| author_facet | Shiho Suzuki Ryo Kimura Shingo Maegawa Masatoshi Nakata Masatoshi Hagiwara |
| author_sort | Shiho Suzuki |
| collection | DOAJ |
| description | Abstract Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study, we examined the behavioral and brain transcriptome changes in MPH-treated and ATX-treated zebrafish. In behavioral analysis, zebrafish showed opposite response to each treatment. MPH-treated fish showed higher anxiety-like behavior while ATX-treated fish showed lower anxiety-like behavior. Further, we performed RNA sequencing analysis of zebrafish brain to elucidate the underlying biological pathways associated with MPH and ATX treatment. Interestingly, we found that shared differentially expressed genes in MPH-treated and ATX-treated fish were instrumental in cholesterol biosynthesis pathway and were regulated in opposite manner. Our findings highlight the contrast between MTH and ATX, and may suggest the alterations in clinical practice for these medications and drug development for ADHD. |
| first_indexed | 2024-12-20T02:05:07Z |
| format | Article |
| id | doaj.art-e86768a3e75849e28e1184bbd2c90f94 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-20T02:05:07Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-e86768a3e75849e28e1184bbd2c90f942022-12-21T19:57:13ZengBMCMolecular Brain1756-66062020-05-011311410.1186/s13041-020-00614-4Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafishShiho Suzuki0Ryo Kimura1Shingo Maegawa2Masatoshi Nakata3Masatoshi Hagiwara4Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto UniversityDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto UniversityDepartment of Intelligence Science and Technology, Graduate School of Informatics, Kyoto UniversityDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto UniversityDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto UniversityAbstract Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study, we examined the behavioral and brain transcriptome changes in MPH-treated and ATX-treated zebrafish. In behavioral analysis, zebrafish showed opposite response to each treatment. MPH-treated fish showed higher anxiety-like behavior while ATX-treated fish showed lower anxiety-like behavior. Further, we performed RNA sequencing analysis of zebrafish brain to elucidate the underlying biological pathways associated with MPH and ATX treatment. Interestingly, we found that shared differentially expressed genes in MPH-treated and ATX-treated fish were instrumental in cholesterol biosynthesis pathway and were regulated in opposite manner. Our findings highlight the contrast between MTH and ATX, and may suggest the alterations in clinical practice for these medications and drug development for ADHD.http://link.springer.com/article/10.1186/s13041-020-00614-4Attention deficit-hyperactivity disorder (ADHD)BehaviorLipid metabolismMethylphenidateAtomoxetineZebrafish |
| spellingShingle | Shiho Suzuki Ryo Kimura Shingo Maegawa Masatoshi Nakata Masatoshi Hagiwara Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish Molecular Brain Attention deficit-hyperactivity disorder (ADHD) Behavior Lipid metabolism Methylphenidate Atomoxetine Zebrafish |
| title | Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| title_full | Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| title_fullStr | Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| title_full_unstemmed | Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| title_short | Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| title_sort | different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish |
| topic | Attention deficit-hyperactivity disorder (ADHD) Behavior Lipid metabolism Methylphenidate Atomoxetine Zebrafish |
| url | http://link.springer.com/article/10.1186/s13041-020-00614-4 |
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