The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran
Background Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian population. Aim To recognise LEP G2548A and LEP receptor Q223R polymorphisms in Iranian people...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-11-01
|
| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2022.2134453 |
| _version_ | 1797685203800424448 |
|---|---|
| author | Parviz Azimnasab-sorkhabi Maryam Soltani-asl José Roberto Kfoury Petra Algenstaedt Hakan Farzin Mehmetzade Yashar Hashemi Aghdam |
| author_facet | Parviz Azimnasab-sorkhabi Maryam Soltani-asl José Roberto Kfoury Petra Algenstaedt Hakan Farzin Mehmetzade Yashar Hashemi Aghdam |
| author_sort | Parviz Azimnasab-sorkhabi |
| collection | DOAJ |
| description | Background Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian population. Aim To recognise LEP G2548A and LEP receptor Q223R polymorphisms in Iranian people and their association with type 1 diabetes susceptibility. Subjects and methods Characteristics such as fasting blood sugar (FBS) were measured in 80 control non-diabetic individuals and 89 diabetic patients. Moreover, LEP G2548A and LEP receptor Q223R polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. Results The frequency of the A allele was nearly three times greater in diabetes patients than in the control group. In addition, in the diabetes group, the AA genotype was five times greater than in the control group (p < 0.01). Furthermore, AA and AA + AG genotype models had higher FBS levels than the GG + AG and GG genotype models, respectively (p < 0.01). Conclusion The LEP G2548A polymorphism could be related to type 1 diabetes susceptibility, but not LEPR Q223R polymorphism in the Iranian population. Importantly, further studies are essential to examine the impact of LEP G2548A and LEPR Q223R polymorphisms in the endocrinology area. |
| first_indexed | 2024-03-12T00:40:46Z |
| format | Article |
| id | doaj.art-e8691ec000f948c9b5365c8457918d1f |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:40:46Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-e8691ec000f948c9b5365c8457918d1f2023-09-15T08:45:20ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332022-11-01497-831732210.1080/03014460.2022.21344532134453The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest IranParviz Azimnasab-sorkhabi0Maryam Soltani-asl1José Roberto Kfoury2Petra Algenstaedt3Hakan Farzin Mehmetzade4Yashar Hashemi Aghdam5Department of Biology, Faculty of Science, Islamic Azad UniversityDepartment of Biology, Faculty of Science, Islamic Azad UniversityDepartment of Surgery, School of Veterinary Medicine and Animal Sciences, University of Sao PauloMedical Clinic and Polyclinic of University of Hamburg, Eppendorf UniversityDepartment of Medical Microbiology, Hacettepe UniversityDepartment of Traumatology, Spine and Orthopedic Surgery, Asklepios Hospital Altona, Faculty of Medicine, University of HamburgBackground Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian population. Aim To recognise LEP G2548A and LEP receptor Q223R polymorphisms in Iranian people and their association with type 1 diabetes susceptibility. Subjects and methods Characteristics such as fasting blood sugar (FBS) were measured in 80 control non-diabetic individuals and 89 diabetic patients. Moreover, LEP G2548A and LEP receptor Q223R polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. Results The frequency of the A allele was nearly three times greater in diabetes patients than in the control group. In addition, in the diabetes group, the AA genotype was five times greater than in the control group (p < 0.01). Furthermore, AA and AA + AG genotype models had higher FBS levels than the GG + AG and GG genotype models, respectively (p < 0.01). Conclusion The LEP G2548A polymorphism could be related to type 1 diabetes susceptibility, but not LEPR Q223R polymorphism in the Iranian population. Importantly, further studies are essential to examine the impact of LEP G2548A and LEPR Q223R polymorphisms in the endocrinology area.http://dx.doi.org/10.1080/03014460.2022.2134453leptinleptin receptorpolymorphismtype 1 diabetes |
| spellingShingle | Parviz Azimnasab-sorkhabi Maryam Soltani-asl José Roberto Kfoury Petra Algenstaedt Hakan Farzin Mehmetzade Yashar Hashemi Aghdam The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran Annals of Human Biology leptin leptin receptor polymorphism type 1 diabetes |
| title | The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran |
| title_full | The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran |
| title_fullStr | The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran |
| title_full_unstemmed | The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran |
| title_short | The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran |
| title_sort | impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest iran |
| topic | leptin leptin receptor polymorphism type 1 diabetes |
| url | http://dx.doi.org/10.1080/03014460.2022.2134453 |
| work_keys_str_mv | AT parvizazimnasabsorkhabi theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT maryamsoltaniasl theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT joserobertokfoury theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT petraalgenstaedt theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT hakanfarzinmehmetzade theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT yasharhashemiaghdam theimpactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT parvizazimnasabsorkhabi impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT maryamsoltaniasl impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT joserobertokfoury impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT petraalgenstaedt impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT hakanfarzinmehmetzade impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran AT yasharhashemiaghdam impactofleptinanditsreceptorpolymorphismsontype1diabetesinapopulationofnorthwestiran |