Natural Products from Red Algal Genus <i>Laurencia</i> as Potential Inhibitors of RdRp and nsp15 Enzymes of SARS-CoV-2: An In Silico Perspective

Natural Products from Red Algal Genus <i>Laurencia</i> as Potential Inhibitors of RdRp and nsp15 Enzymes of SARS-CoV-2: An In Silico Perspective

The genus <i>Laurencia</i>, a category of marine red algae, is well recognized for producing a large variety of natural products (NPs) that are both chemically intriguing and structurally distinct. The aim of this research was to identify NPs with potential anti-SARS-CoV-2 activity. The...

Full description

Bibliographic Details
Main Authors:	Omkar Pokharkar, Harshavardhan Anumolu, Grigory V. Zyryanov, Mikhail V. Tsurkan
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	Microbiology Research
Subjects:	COVID-19 SARS-CoV-2 RdRp Nsp12 Nsp15 endoribonuclease
Online Access:	https://www.mdpi.com/2036-7481/14/3/69

Similar Items

Antiviral Potential of <i>Antillogorgia americana</i> and <i>elisabethae</i> Natural Products against nsp16–nsp10 Complex, nsp13, and nsp14 Proteins of SARS-CoV-2: An In Silico Investigation
by: Omkar Pokharkar, et al.
Published: (2023-07-01)

Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus
by: Huiyang Sha, et al.
Published: (2022-07-01)

Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication
by: Yan Wang, et al.
Published: (2020-11-01)

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation
by: Shangxin Yang, et al.
Published: (2023-08-01)

Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp)
by: Anandakrishnan Karthic, et al.
Published: (2022-01-01)

Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence
by: Yunfei Xie, et al.
Published: (2023-12-01)

Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15
by: D. Anantha Krishnan, et al.
Published: (2020-01-01)

Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2
by: Abdulelah Aljuaid, et al.
Published: (2022-11-01)

Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp
by: Zhuang Wang, et al.
Published: (2022-06-01)

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities
by: Chen, Ming Wei, et al.
Published: (2017)

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication
by: Yaoming Li, et al.
Published: (2019-01-01)

Structural insights into SARS-CoV-2 infection and therapeutics development
by: Gangyu Sun, et al.
Published: (2021-04-01)

Triple targeting of human IMPDH, SARS-CoV-2 RdRp, and Rhizopus oryzae RdRp: An in silico perspective
by: Abdel-moniem S. Hassan, et al.
Published: (2023-12-01)

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
by: Jie Yuan, et al.
Published: (2020-07-01)

In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis
by: Rami J. Obaid, et al.
Published: (2023-03-01)

The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19
by: Michał Majchrzak, et al.
Published: (2024-03-01)

Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load
by: Doğa Eskier, et al.
Published: (2020-10-01)

Evaluation of the Binding Relationship of the RdRp Enzyme to Novel Thiazole/Acid Hydrazone Hybrids Obtainable through Green Synthetic Procedure
by: Jehan Y. Al-Humaidi, et al.
Published: (2022-08-01)

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
by: Shenghua Gao, et al.
Published: (2022-12-01)

Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors
by: Keli Zong, et al.
Published: (2023-11-01)

SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
by: Jung Sun Min, et al.
Published: (2021-08-01)

Association of rotavirus viroplasms with microtubules through NSP2 and NSP5
by: Claudio Cabral-Romero, et al.
Published: (2006-09-01)

RdRp mutations are associated with SARS-CoV-2 genome evolution
by: Doğa Eskier, et al.
Published: (2020-07-01)

Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo
by: Troy von Beck, et al.
Published: (2023-08-01)

An Efficient Modern Strategy to Screen Drug Candidates Targeting RdRp of SARS-CoV-2 With Potentially High Selectivity and Specificity
by: Haiping Zhang, et al.
Published: (2022-07-01)

Development of a Viral RdRp-Assisted Gene Silencing System and Its Application in the Identification of Host Factors of Plant (+)RNA Virus
by: Wang Zhang, et al.
Published: (2021-07-01)

Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay
by: Timsy Uppal, et al.
Published: (2022-08-01)

Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp
by: Bangdi Zhou, et al.
Published: (2024-02-01)

Derivation, Functionalization of (S)-Goniothalamin from <i>Goniothalamus wightii</i> and Their Derivative Targets SARS-CoV-2 M<sup>Pro</sup>, S<sup>Pro</sup>, and RdRp: A Pharmacological Perspective
by: Vino Palani, et al.
Published: (2022-10-01)

Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit
by: Vladimira Horova, et al.
Published: (2021-07-01)

Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2
by: Ahmed H. Bakheit, et al.
Published: (2023-10-01)

Repurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations
by: Soodeh Mahdian, et al.
Published: (2021-01-01)

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity
by: Yujiao Zhang, et al.
Published: (2020-06-01)

Comparative Transcriptomic and Molecular Pathway Analyses of HL-CZ Human Pro-Monocytic Cells Expressing SARS-CoV-2 Spike S1, S2, NP, NSP15 and NSP16 Genes
by: Anshika Sharma, et al.
Published: (2021-05-01)

Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors
by: Amarender Manchoju, et al.
Published: (2022-01-01)

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
by: Francesca Picarazzi, et al.
Published: (2020-12-01)

Virtual screening based on the structure of more than 105 compounds against four key proteins of SARS-CoV-2: MPro, SRBD, RdRp, and PLpro
by: Farzan Nabati, et al.
Published: (2022-01-01)

Bio-Chemoinformatics-Driven Analysis of nsp7 and nsp8 Mutations and Their Effects on Viral Replication Protein Complex Stability
by: Bryan John J. Subong, et al.
Published: (2024-03-01)

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure
by: Gyanendra Bahadur Chand, et al.
Published: (2020-07-01)

Structure of the RSV Polymerase Complex Reveals a Tentacular Arrangement of the Viral Phosphoprotein
by: Jason S. McLellan
Published: (2020-07-01)