Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials
Introduction Noise-induced hearing loss is one of the most prevalent causes of hearing impairment and occupational diseases. Although multiple factors lead to noise-induced hearing loss, prevention and protection strategies remain limited. Studies in the past decade have employed antioxidants, espec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Effect-of-N-acetyl-cysteine-in-prevention-of-noise-induced-hearing-loss-a-systematic,109126,0,2.html |
| _version_ | 1797435352080711680 |
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| author | Po-Hsiung Chang Chia-Wei Liu Shih-Han Hung Yi-No Kang |
| author_facet | Po-Hsiung Chang Chia-Wei Liu Shih-Han Hung Yi-No Kang |
| author_sort | Po-Hsiung Chang |
| collection | DOAJ |
| description | Introduction
Noise-induced hearing loss is one of the most prevalent causes of hearing impairment and occupational diseases. Although multiple factors lead to noise-induced hearing loss, prevention and protection strategies remain limited. Studies in the past decade have employed antioxidants, especially N-acetyl-cysteine, to prevent noise-induced hearing loss. Therefore, this systematic review and meta-analysis of randomized controlled trials evaluated the effect of N-acetyl-cysteine on the prevention of noise-induced hearing loss.
Material and methods
This systematic review and meta-analysis included relevant studies from the Cochrane Library, EMBASE, PubMed, ScienceDirect, Scopus, and Web of Science by using related terms. The study only included randomized controlled trials in meta-analyses and assessed the quality of the identified randomized controlled trials by using the Cochrane Risk of Bias tool. Two authors extracted and calculated data on characteristics and hearing threshold. The results are presented as weighted mean difference (WMD) with 95% confidence interval (CI).
Results
This study identified five randomized controlled trials that randomized 1,115 patients into N-acetyl-cysteine and control groups. The meta-analysis evidenced that N-acetyl-cysteine has greater protective effects against hearing threshold shifts than the control in the 0 to 4 kHz (WMD = –3.39, 95% CI: –6.56 to –0.22) and 0 to 6 kHz (MD = –3.49, 95% CI: –6.57 to –0.41) subgroups.
Conclusions
The present review and meta-analysis recommends that N-acetyl-cysteine may be considered as an option for protective therapy for noise-induced hearing loss. Nonetheless, larger randomized controlled trials are requisite for further investigation and verification. |
| first_indexed | 2024-03-09T10:46:57Z |
| format | Article |
| id | doaj.art-e869fadc2ad449e3acf3414bb303359a |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:57Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-e869fadc2ad449e3acf3414bb303359a2023-12-01T09:59:22ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-011861535154110.5114/aoms/109126109126Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trialsPo-Hsiung Chang0Chia-Wei Liu1Shih-Han Hung2Yi-No Kang3Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCochrane Taiwan, Taipei Medical University, Taipei, TaiwanIntroduction Noise-induced hearing loss is one of the most prevalent causes of hearing impairment and occupational diseases. Although multiple factors lead to noise-induced hearing loss, prevention and protection strategies remain limited. Studies in the past decade have employed antioxidants, especially N-acetyl-cysteine, to prevent noise-induced hearing loss. Therefore, this systematic review and meta-analysis of randomized controlled trials evaluated the effect of N-acetyl-cysteine on the prevention of noise-induced hearing loss. Material and methods This systematic review and meta-analysis included relevant studies from the Cochrane Library, EMBASE, PubMed, ScienceDirect, Scopus, and Web of Science by using related terms. The study only included randomized controlled trials in meta-analyses and assessed the quality of the identified randomized controlled trials by using the Cochrane Risk of Bias tool. Two authors extracted and calculated data on characteristics and hearing threshold. The results are presented as weighted mean difference (WMD) with 95% confidence interval (CI). Results This study identified five randomized controlled trials that randomized 1,115 patients into N-acetyl-cysteine and control groups. The meta-analysis evidenced that N-acetyl-cysteine has greater protective effects against hearing threshold shifts than the control in the 0 to 4 kHz (WMD = –3.39, 95% CI: –6.56 to –0.22) and 0 to 6 kHz (MD = –3.49, 95% CI: –6.57 to –0.41) subgroups. Conclusions The present review and meta-analysis recommends that N-acetyl-cysteine may be considered as an option for protective therapy for noise-induced hearing loss. Nonetheless, larger randomized controlled trials are requisite for further investigation and verification.https://www.archivesofmedicalscience.com/Effect-of-N-acetyl-cysteine-in-prevention-of-noise-induced-hearing-loss-a-systematic,109126,0,2.htmln-acetyl-cysteineantioxidantsnoise-induced hearing loss |
| spellingShingle | Po-Hsiung Chang Chia-Wei Liu Shih-Han Hung Yi-No Kang Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials Archives of Medical Science n-acetyl-cysteine antioxidants noise-induced hearing loss |
| title | Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | effect of n acetyl cysteine in prevention of noise induced hearing loss a systematic review and meta analysis of randomized controlled trials |
| topic | n-acetyl-cysteine antioxidants noise-induced hearing loss |
| url | https://www.archivesofmedicalscience.com/Effect-of-N-acetyl-cysteine-in-prevention-of-noise-induced-hearing-loss-a-systematic,109126,0,2.html |
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