Chemical Synthesis, Proper Folding, Na<sub>v</sub> Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (<i>Phlogius</i> species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging, mostly for obtaining appropri...

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Bibliographic Details
Main Authors:	Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Toxins
Subjects:	spider toxin directed disulfide bond formation Na<sub>v</sub> channel activity Na<sub>v</sub>1.7 pain target automated patch-clamp
Online Access:	https://www.mdpi.com/2072-6651/11/6/367

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