In vivo targeting of protein antigens to dendritic cells using anti‐DEC‐205 single chain antibody improves HIV Gag specific CD4+ T cell responses protecting from airway challenge with recombinant vaccinia‐gag virus

In vivo targeting of protein antigens to dendritic cells using anti‐DEC‐205 single chain antibody improves HIV Gag specific CD4+ T cell responses protecting from airway challenge with recombinant vaccinia‐gag virus

Abstract Introduction Targeting antigens to dendritic cells (DCs) in vivo via a DC‐restricted endocytic receptor, DEC205, has been validated to enhance immunity in several vaccine platforms. Particularly atttractive is selected delivery of proteins to DCs in vivo because it enables proteins to be mo...

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Bibliographic Details
Main Authors: Loveline N. Ngu, Nadesh N. Nji, Georgia E. Ambada, Bertrand Sagnia, Carol Ngane Sake, Jules Colinc Tchadji, Ghislain Donald Njambe Priso, Abel Lissom, Thibau Flaurant Tchouangueu, Denis Manga Tebit, Alain Bopda Waffo, Chae Gyu Park, Ralph M. Steinman, Klaus Überla, Godwin W. Nchinda
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Immunity, Inflammation and Disease
Subjects:
Antigens
dendritic cells
immunization
Online Access:https://doi.org/10.1002/iid3.151

Internet

https://doi.org/10.1002/iid3.151

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