Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach
Cross-sectional studies have reported lower brain grey matter volumes (GMV) and white matter volumes (WMV) in preterm (PT) born individuals. While large MRI studies in the normative population have led to a better understanding of brain growth trajectories across the lifespan, such results remain el...
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MDPI AG
2021-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/9/868 |
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| author | Benita Schmitz-Koep Bernhard Haller Pierrick Coupé Aurore Menegaux Christian Gaser Claus Zimmer Dieter Wolke Peter Bartmann Christian Sorg Dennis M. Hedderich |
| author_facet | Benita Schmitz-Koep Bernhard Haller Pierrick Coupé Aurore Menegaux Christian Gaser Claus Zimmer Dieter Wolke Peter Bartmann Christian Sorg Dennis M. Hedderich |
| author_sort | Benita Schmitz-Koep |
| collection | DOAJ |
| description | Cross-sectional studies have reported lower brain grey matter volumes (GMV) and white matter volumes (WMV) in preterm (PT) born individuals. While large MRI studies in the normative population have led to a better understanding of brain growth trajectories across the lifespan, such results remain elusive for PT born individuals since large, aggregated datasets of PT born individuals do not exist. To close this gap, we investigated GMV and WMV in PT born individuals as reported in the literature and contrasted it against individual volumetric data and trajectories from the general population. Systematic database search of PubMed and Web of Science in March 2021, and extraction of outcome measures were conducted by two independent reviewers. Individual data on full-term (FT) controls was extracted from freely available databases. Mean GMV, WMV, total intracranial volume (TIV), and mean age at scan were the main outcome measures. Of 532 identified records, nine studies were included with 538 PT born subjects between 1.1 and 28.5 years of age. Reference data was generated from 880 FT controls between 1 and 30 years of age. GMV was consistently lower in PT born individuals from infancy to early adulthood with no evidence for catch-up growth. While GMV changes followed a similar trajectory as FT controls, WMV was particularly low in adolescence after PT birth. Results demonstrate altered brain volumes after PT birth across the first half of lifespan. Future studies should address this issue in large aggregated datasets of PT born individuals. |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T07:32:24Z |
| publishDate | 2021-08-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-e86e454dec1d4b2e99a9740be0bf3e292023-11-22T13:50:20ZengMDPI AGJournal of Personalized Medicine2075-44262021-08-0111986810.3390/jpm11090868Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic ApproachBenita Schmitz-Koep0Bernhard Haller1Pierrick Coupé2Aurore Menegaux3Christian Gaser4Claus Zimmer5Dieter Wolke6Peter Bartmann7Christian Sorg8Dennis M. Hedderich9Department of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyInstitute of Medical Informatics, Statistics and Epidemiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyLaboratoire Bordelais de Recherche en Informatique (LaBRI) UMR 5800, CNRS, Bordeaux INP, University of Bordeaux, F-33400 Talence, FranceDepartment of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Psychiatry, University Hospital Jena, Am Klinikum 1, 07747 Jena, GermanyDepartment of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Psychology, University of Warwick, University Road, Coventry CV4 7AL, UKDepartment of Neonatology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyDepartment of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyCross-sectional studies have reported lower brain grey matter volumes (GMV) and white matter volumes (WMV) in preterm (PT) born individuals. While large MRI studies in the normative population have led to a better understanding of brain growth trajectories across the lifespan, such results remain elusive for PT born individuals since large, aggregated datasets of PT born individuals do not exist. To close this gap, we investigated GMV and WMV in PT born individuals as reported in the literature and contrasted it against individual volumetric data and trajectories from the general population. Systematic database search of PubMed and Web of Science in March 2021, and extraction of outcome measures were conducted by two independent reviewers. Individual data on full-term (FT) controls was extracted from freely available databases. Mean GMV, WMV, total intracranial volume (TIV), and mean age at scan were the main outcome measures. Of 532 identified records, nine studies were included with 538 PT born subjects between 1.1 and 28.5 years of age. Reference data was generated from 880 FT controls between 1 and 30 years of age. GMV was consistently lower in PT born individuals from infancy to early adulthood with no evidence for catch-up growth. While GMV changes followed a similar trajectory as FT controls, WMV was particularly low in adolescence after PT birth. Results demonstrate altered brain volumes after PT birth across the first half of lifespan. Future studies should address this issue in large aggregated datasets of PT born individuals.https://www.mdpi.com/2075-4426/11/9/868brain developmentgrey matter volumewhite matter volumestructural magnetic resonance imagingpreterm birth |
| spellingShingle | Benita Schmitz-Koep Bernhard Haller Pierrick Coupé Aurore Menegaux Christian Gaser Claus Zimmer Dieter Wolke Peter Bartmann Christian Sorg Dennis M. Hedderich Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach Journal of Personalized Medicine brain development grey matter volume white matter volume structural magnetic resonance imaging preterm birth |
| title | Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach |
| title_full | Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach |
| title_fullStr | Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach |
| title_full_unstemmed | Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach |
| title_short | Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach |
| title_sort | grey and white matter volume changes after preterm birth a meta analytic approach |
| topic | brain development grey matter volume white matter volume structural magnetic resonance imaging preterm birth |
| url | https://www.mdpi.com/2075-4426/11/9/868 |
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