From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures
Background: Tractography has been widely adopted to improve brain gliomas' surgical planning and guide their resection. This study aimed to evaluate state-of-the-art of arcuate fasciculus (AF) tractography for surgical planning and explore the role of along-tract analyses in vivo for characteri...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.633209/full |
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| author | Matteo Zoli Matteo Zoli Lia Talozzi Matteo Martinoni David N. Manners Filippo Badaloni Claudia Testa Sofia Asioli Sofia Asioli Micaela Mitolo Fiorina Bartiromo Magali Jane Rochat Viscardo Paolo Fabbri Carmelo Sturiale Alfredo Conti Alfredo Conti Raffaele Lodi Raffaele Lodi Diego Mazzatenta Diego Mazzatenta Caterina Tonon Caterina Tonon |
| author_facet | Matteo Zoli Matteo Zoli Lia Talozzi Matteo Martinoni David N. Manners Filippo Badaloni Claudia Testa Sofia Asioli Sofia Asioli Micaela Mitolo Fiorina Bartiromo Magali Jane Rochat Viscardo Paolo Fabbri Carmelo Sturiale Alfredo Conti Alfredo Conti Raffaele Lodi Raffaele Lodi Diego Mazzatenta Diego Mazzatenta Caterina Tonon Caterina Tonon |
| author_sort | Matteo Zoli |
| collection | DOAJ |
| description | Background: Tractography has been widely adopted to improve brain gliomas' surgical planning and guide their resection. This study aimed to evaluate state-of-the-art of arcuate fasciculus (AF) tractography for surgical planning and explore the role of along-tract analyses in vivo for characterizing tumor histopathology.Methods: High angular resolution diffusion imaging (HARDI) images were acquired for nine patients with tumors located in or near language areas (age: 41 ± 14 years, mean ± standard deviation; five males) and 32 healthy volunteers (age: 39 ± 16 years; 16 males). Phonemic fluency task fMRI was acquired preoperatively for patients. AF tractography was performed using constrained spherical deconvolution diffusivity modeling and probabilistic fiber tracking. Along-tract analyses were performed, dividing the AF into 15 segments along the length of the tract defined using the Laplacian operator. For each AF segment, diffusion tensor imaging (DTI) measures were compared with those obtained in healthy controls (HCs). The hemispheric laterality index (LI) was calculated from language task fMRI activations in the frontal, parietal, and temporal lobe parcellations. Tumors were grouped into low/high grade (LG/HG).Results: Four tumors were LG gliomas (one dysembryoplastic neuroepithelial tumor and three glioma grade II) and five HG gliomas (two grade III and three grade IV). For LG tumors, gross total removal was achieved in all but one case, for HG in two patients. Tractography identified the AF trajectory in all cases. Four along-tract DTI measures potentially discriminated LG and HG tumor patients (false discovery rate < 0.1): the number of abnormal MD and RD segments, median AD, and MD measures. Both a higher number of abnormal AF segments and a higher AD and MD measures were associated with HG tumor patients. Moreover, correlations (unadjusted p < 0.05) were found between the parietal lobe LI and the DTI measures, which discriminated between LG and HG tumor patients. In particular, a more rightward parietal lobe activation (LI < 0) correlated with a higher number of abnormal MD segments (R = −0.732) and RD segments (R = −0.724).Conclusions: AF tractography allows to detect the course of the tract, favoring the safer-as-possible tumor resection. Our preliminary study shows that along-tract DTI metrics can provide useful information for differentiating LG and HG tumors during pre-surgical tumor characterization. |
| first_indexed | 2024-12-19T10:59:19Z |
| format | Article |
| id | doaj.art-e86f3175757a477da3f80c047fa2df8d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T10:59:19Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e86f3175757a477da3f80c047fa2df8d2022-12-21T20:24:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-02-011210.3389/fneur.2021.633209633209From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography MeasuresMatteo Zoli0Matteo Zoli1Lia Talozzi2Matteo Martinoni3David N. Manners4Filippo Badaloni5Claudia Testa6Sofia Asioli7Sofia Asioli8Micaela Mitolo9Fiorina Bartiromo10Magali Jane Rochat11Viscardo Paolo Fabbri12Carmelo Sturiale13Alfredo Conti14Alfredo Conti15Raffaele Lodi16Raffaele Lodi17Diego Mazzatenta18Diego Mazzatenta19Caterina Tonon20Caterina Tonon21Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyNeurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyNeurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Physics and Astronomy, University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyAnatomic Pathology Unit, Azienda USL di Bologna, Bologna, ItalyFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyNeurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyNeurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyPituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalyFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyBackground: Tractography has been widely adopted to improve brain gliomas' surgical planning and guide their resection. This study aimed to evaluate state-of-the-art of arcuate fasciculus (AF) tractography for surgical planning and explore the role of along-tract analyses in vivo for characterizing tumor histopathology.Methods: High angular resolution diffusion imaging (HARDI) images were acquired for nine patients with tumors located in or near language areas (age: 41 ± 14 years, mean ± standard deviation; five males) and 32 healthy volunteers (age: 39 ± 16 years; 16 males). Phonemic fluency task fMRI was acquired preoperatively for patients. AF tractography was performed using constrained spherical deconvolution diffusivity modeling and probabilistic fiber tracking. Along-tract analyses were performed, dividing the AF into 15 segments along the length of the tract defined using the Laplacian operator. For each AF segment, diffusion tensor imaging (DTI) measures were compared with those obtained in healthy controls (HCs). The hemispheric laterality index (LI) was calculated from language task fMRI activations in the frontal, parietal, and temporal lobe parcellations. Tumors were grouped into low/high grade (LG/HG).Results: Four tumors were LG gliomas (one dysembryoplastic neuroepithelial tumor and three glioma grade II) and five HG gliomas (two grade III and three grade IV). For LG tumors, gross total removal was achieved in all but one case, for HG in two patients. Tractography identified the AF trajectory in all cases. Four along-tract DTI measures potentially discriminated LG and HG tumor patients (false discovery rate < 0.1): the number of abnormal MD and RD segments, median AD, and MD measures. Both a higher number of abnormal AF segments and a higher AD and MD measures were associated with HG tumor patients. Moreover, correlations (unadjusted p < 0.05) were found between the parietal lobe LI and the DTI measures, which discriminated between LG and HG tumor patients. In particular, a more rightward parietal lobe activation (LI < 0) correlated with a higher number of abnormal MD segments (R = −0.732) and RD segments (R = −0.724).Conclusions: AF tractography allows to detect the course of the tract, favoring the safer-as-possible tumor resection. Our preliminary study shows that along-tract DTI metrics can provide useful information for differentiating LG and HG tumors during pre-surgical tumor characterization.https://www.frontiersin.org/articles/10.3389/fneur.2021.633209/fullneurosurgerytractographyarcuate fasciculusalong-tractgliomas gradinglanguage network |
| spellingShingle | Matteo Zoli Matteo Zoli Lia Talozzi Matteo Martinoni David N. Manners Filippo Badaloni Claudia Testa Sofia Asioli Sofia Asioli Micaela Mitolo Fiorina Bartiromo Magali Jane Rochat Viscardo Paolo Fabbri Carmelo Sturiale Alfredo Conti Alfredo Conti Raffaele Lodi Raffaele Lodi Diego Mazzatenta Diego Mazzatenta Caterina Tonon Caterina Tonon From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures Frontiers in Neurology neurosurgery tractography arcuate fasciculus along-tract gliomas grading language network |
| title | From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures |
| title_full | From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures |
| title_fullStr | From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures |
| title_full_unstemmed | From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures |
| title_short | From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures |
| title_sort | from neurosurgical planning to histopathological brain tumor characterization potentialities of arcuate fasciculus along tract diffusion tensor imaging tractography measures |
| topic | neurosurgery tractography arcuate fasciculus along-tract gliomas grading language network |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.633209/full |
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