Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases
Cancer and cardiovascular diseases (CVD) account for approximately 27.5 million deaths every year. While they share some common environmental risk factors, their shared genetic risk factors are not yet fully understood. The aim of the present study was to aggregate genetic risk factors associated wi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.931917/full |
| _version_ | 1818113190935920640 |
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| author | Aleksander Turk Tanja Kunej |
| author_facet | Aleksander Turk Tanja Kunej |
| author_sort | Aleksander Turk |
| collection | DOAJ |
| description | Cancer and cardiovascular diseases (CVD) account for approximately 27.5 million deaths every year. While they share some common environmental risk factors, their shared genetic risk factors are not yet fully understood. The aim of the present study was to aggregate genetic risk factors associated with the comorbidity of cancer and CVDs. For this purpose, we: (1) created a catalog of genes associated with cancer and CVDs, (2) visualized retrieved data as a gene-disease network, and (3) performed a pathway enrichment analysis. We performed screening of PubMed database for literature reporting genetic risk factors in patients with both cancer and CVD. The gene-disease network was visualized using Cytoscape and the enrichment analysis was conducted using Enrichr software. We manually reviewed the 181 articles fitting the search criteria and included 13 articles in the study. Data visualization revealed a highly interconnected network containing a single subnetwork with 56 nodes and 146 edges. Genes in the network with the highest number of disease interactions were JAK2, TTN, TET2, and ATM. The pathway enrichment analysis revealed that genes included in the study were significantly enriched in DNA damage repair (DDR) pathways, such as homologous recombination. The role of DDR mechanisms in the development of CVDs has been studied in previously published research; however, additional functional studies are required to elucidate their contribution to the pathophysiology to CVDs. |
| first_indexed | 2024-12-11T03:30:54Z |
| format | Article |
| id | doaj.art-e86fc98fe1174931aecbc6d2ce646d2e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T03:30:54Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e86fc98fe1174931aecbc6d2ce646d2e2022-12-22T01:22:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.931917931917Shared Genetic Risk Factors Between Cancer and Cardiovascular DiseasesAleksander TurkTanja KunejCancer and cardiovascular diseases (CVD) account for approximately 27.5 million deaths every year. While they share some common environmental risk factors, their shared genetic risk factors are not yet fully understood. The aim of the present study was to aggregate genetic risk factors associated with the comorbidity of cancer and CVDs. For this purpose, we: (1) created a catalog of genes associated with cancer and CVDs, (2) visualized retrieved data as a gene-disease network, and (3) performed a pathway enrichment analysis. We performed screening of PubMed database for literature reporting genetic risk factors in patients with both cancer and CVD. The gene-disease network was visualized using Cytoscape and the enrichment analysis was conducted using Enrichr software. We manually reviewed the 181 articles fitting the search criteria and included 13 articles in the study. Data visualization revealed a highly interconnected network containing a single subnetwork with 56 nodes and 146 edges. Genes in the network with the highest number of disease interactions were JAK2, TTN, TET2, and ATM. The pathway enrichment analysis revealed that genes included in the study were significantly enriched in DNA damage repair (DDR) pathways, such as homologous recombination. The role of DDR mechanisms in the development of CVDs has been studied in previously published research; however, additional functional studies are required to elucidate their contribution to the pathophysiology to CVDs.https://www.frontiersin.org/articles/10.3389/fcvm.2022.931917/fullcancercardiovascular diseaserisk factorchemotherapycomorbiditygenetic variant |
| spellingShingle | Aleksander Turk Tanja Kunej Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases Frontiers in Cardiovascular Medicine cancer cardiovascular disease risk factor chemotherapy comorbidity genetic variant |
| title | Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases |
| title_full | Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases |
| title_fullStr | Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases |
| title_full_unstemmed | Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases |
| title_short | Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases |
| title_sort | shared genetic risk factors between cancer and cardiovascular diseases |
| topic | cancer cardiovascular disease risk factor chemotherapy comorbidity genetic variant |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.931917/full |
| work_keys_str_mv | AT aleksanderturk sharedgeneticriskfactorsbetweencancerandcardiovasculardiseases AT tanjakunej sharedgeneticriskfactorsbetweencancerandcardiovasculardiseases |