Association between gut microbiota and glioblastoma: a Mendelian randomization study
Background: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting the physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota and the development of GBM. In this investigation, Mendelian randomization (...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1308263/full |
| _version_ | 1797366624873873408 |
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| author | Song Wang Fangxu Yin Zheng Guo Rui Li Wei Sun Yuchao Wang Yichen Geng Chao Sun Daqing Sun |
| author_facet | Song Wang Fangxu Yin Zheng Guo Rui Li Wei Sun Yuchao Wang Yichen Geng Chao Sun Daqing Sun |
| author_sort | Song Wang |
| collection | DOAJ |
| description | Background: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting the physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota and the development of GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate the potential causal relationship between gut microbiota and GBM.Methods: We utilized summary statistics derived from genome-wide association studies (GWAS) encompassing 211 gut microbiota and GBM. The causal association between gut microbiota and GBM was scrutinized using Inverse Variance Weighted (IVW), MR-Egger, and Weighted Median (WM) methods. Cochrane’s Q statistic was employed to conduct a heterogeneity test. MR-Pleiotropic Residuals and Outliers (MR-PRESSO) were applied to identify and eliminate SNPs with horizontal pleiotropic outliers. Additionally, Reverse MR was employed to assess the causal relationship between GBM and pertinent gut microbiota.Results: The MR study estimates suggest that the nine gut microbiota remain stable, considering heterogeneity and sensitivity methods. Among these, the family.Peptostreptococcaceae and genus.Eubacterium brachy group were associated with an increased risk of GBM, whereas family.Ruminococcaceae, genus.Anaerostipes, genus.Faecalibacterium, genus.LachnospiraceaeUCG004, genus.Phascolarctobacterium, genus.Prevotella7, and genus.Streptococcus were associated with a reduced risk of GBM. Following Benjamini and Hochberg (BH) correction, family.Ruminococcaceae (OR = 0.04, 95% CI: 0.01–0.19, FDR = 0.003) was identified as playing a protective role against GBM.Conclusion: This groundbreaking study is the first to demonstrate that family.Ruminococcaceae is significantly associated with a reduced risk of GBM. The modulation of family_Ruminococcaceae for the treatment of GBM holds considerable potential clinical significance. |
| first_indexed | 2024-03-08T17:06:23Z |
| format | Article |
| id | doaj.art-e870bde7e37f4068959bece9fe5cce5b |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-08T17:06:23Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e870bde7e37f4068959bece9fe5cce5b2024-01-04T05:02:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-01-011410.3389/fgene.2023.13082631308263Association between gut microbiota and glioblastoma: a Mendelian randomization studySong Wang0Fangxu Yin1Zheng Guo2Rui Li3Wei Sun4Yuchao Wang5Yichen Geng6Chao Sun7Daqing Sun8Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaNursing College of Binzhou Medical University, Yantai, Shandong, ChinaDepartment of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaBackground: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting the physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota and the development of GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate the potential causal relationship between gut microbiota and GBM.Methods: We utilized summary statistics derived from genome-wide association studies (GWAS) encompassing 211 gut microbiota and GBM. The causal association between gut microbiota and GBM was scrutinized using Inverse Variance Weighted (IVW), MR-Egger, and Weighted Median (WM) methods. Cochrane’s Q statistic was employed to conduct a heterogeneity test. MR-Pleiotropic Residuals and Outliers (MR-PRESSO) were applied to identify and eliminate SNPs with horizontal pleiotropic outliers. Additionally, Reverse MR was employed to assess the causal relationship between GBM and pertinent gut microbiota.Results: The MR study estimates suggest that the nine gut microbiota remain stable, considering heterogeneity and sensitivity methods. Among these, the family.Peptostreptococcaceae and genus.Eubacterium brachy group were associated with an increased risk of GBM, whereas family.Ruminococcaceae, genus.Anaerostipes, genus.Faecalibacterium, genus.LachnospiraceaeUCG004, genus.Phascolarctobacterium, genus.Prevotella7, and genus.Streptococcus were associated with a reduced risk of GBM. Following Benjamini and Hochberg (BH) correction, family.Ruminococcaceae (OR = 0.04, 95% CI: 0.01–0.19, FDR = 0.003) was identified as playing a protective role against GBM.Conclusion: This groundbreaking study is the first to demonstrate that family.Ruminococcaceae is significantly associated with a reduced risk of GBM. The modulation of family_Ruminococcaceae for the treatment of GBM holds considerable potential clinical significance.https://www.frontiersin.org/articles/10.3389/fgene.2023.1308263/fullglioblastomagut microbiotagut-brain axisMendelian randomizationcausality |
| spellingShingle | Song Wang Fangxu Yin Zheng Guo Rui Li Wei Sun Yuchao Wang Yichen Geng Chao Sun Daqing Sun Association between gut microbiota and glioblastoma: a Mendelian randomization study Frontiers in Genetics glioblastoma gut microbiota gut-brain axis Mendelian randomization causality |
| title | Association between gut microbiota and glioblastoma: a Mendelian randomization study |
| title_full | Association between gut microbiota and glioblastoma: a Mendelian randomization study |
| title_fullStr | Association between gut microbiota and glioblastoma: a Mendelian randomization study |
| title_full_unstemmed | Association between gut microbiota and glioblastoma: a Mendelian randomization study |
| title_short | Association between gut microbiota and glioblastoma: a Mendelian randomization study |
| title_sort | association between gut microbiota and glioblastoma a mendelian randomization study |
| topic | glioblastoma gut microbiota gut-brain axis Mendelian randomization causality |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1308263/full |
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