Inhibitors of IFN gene stimulators (STING) improve intestinal ischemia–reperfusion-induced acute lung injury by activating AMPK signaling

Inhibitors of IFN gene stimulators (STING) improve intestinal ischemia–reperfusion-induced acute lung injury by activating AMPK signaling

Abstract Background Acute lung injury (ALI) caused by intestinal ischemia–reperfusion is a life-threatening disease. Interferon gene stimulator (STING) is a cytoplasmic DNA sensor that participates in the initiation of the inflammatory response. This study aims to establish whether C-176 (STING inhi...

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Bibliographic Details
Main Authors: Mei Yang, Yu-Xia Ma, Ying Zhi, Hai-Bin Wang, Li Zhao, Peng-Sheng Wang, Jie-Ting Niu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:European Journal of Medical Research
Subjects:
Acute lung injury
Intestinal ischemia–reperfusion
STING
AMPK
Inflammation
Online Access:https://doi.org/10.1186/s40001-022-00703-1

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