A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid
The article is devoted to research on the synthesis of hydroxyquinoline derivative based on 8-oxyquinoline and maleic anhydride. Analysis of available literature was carried out, some drugs were found that are produced based on hydroxyquinoline derivatives and have antiprotozoal, antimicrobial and...
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| Format: | Article |
| Language: | English |
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al-Farabi Kazakh National University
2022-03-01
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| Series: | Eurasian Chemico-Technological Journal |
| Subjects: | |
| Online Access: | https://ect-journal.kz/index.php/ectj/article/view/1148 |
| _version_ | 1811294656856588288 |
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| author | V.V. Merkulov A.I. Almazov S.K. Kabiyeva S.N. Mantler V.V. Konshin |
| author_facet | V.V. Merkulov A.I. Almazov S.K. Kabiyeva S.N. Mantler V.V. Konshin |
| author_sort | V.V. Merkulov |
| collection | DOAJ |
| description |
The article is devoted to research on the synthesis of hydroxyquinoline derivative based on 8-oxyquinoline and maleic anhydride. Analysis of available literature was carried out, some drugs were found that are produced based on hydroxyquinoline derivatives and have antiprotozoal, antimicrobial and antiseptic effects, used alone or in combination with other active substances. A technique has been developed for the synthesis of a new derivative in the medium of petroleum distillate using sulfuric acid as a catalyst. A water-soluble ester of 8-oxyquinoline and maleic acid was obtained in good yield (95%), the structure of which was established based on UV, IR and NMR spectroscopy. By analogy with other oxyquinoline derivatives and the results of prediction bioactivity in the PASS program, the obtained derivative may be characterized by antifungal (antiseborrheic) action. It was determined its antibacterial properties at a concentration of 20.0–10.0 mg/cm3 as well as a significant antioxidant activity which is a useful biological property to expand the range of its application.
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| first_indexed | 2024-04-13T05:20:41Z |
| format | Article |
| id | doaj.art-e871d22aeb5249f2b677d75ac3f175e7 |
| institution | Directory Open Access Journal |
| issn | 1562-3920 2522-4867 |
| language | English |
| last_indexed | 2024-04-13T05:20:41Z |
| publishDate | 2022-03-01 |
| publisher | al-Farabi Kazakh National University |
| record_format | Article |
| series | Eurasian Chemico-Technological Journal |
| spelling | doaj.art-e871d22aeb5249f2b677d75ac3f175e72022-12-22T03:00:46Zengal-Farabi Kazakh National UniversityEurasian Chemico-Technological Journal1562-39202522-48672022-03-0124110.18321/ectj1148A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acidV.V. Merkulov0A.I. Almazov1S.K. Kabiyeva2S.N. Mantler3V.V. Konshin4Karaganda Industrial University, 30, Republic Ave., Temirtau, KazakhstanKaraganda Industrial University, 30, Republic Ave., Temirtau, KazakhstanKaraganda Industrial University, 30, Republic Ave., Temirtau, KazakhstanKaraganda Industrial University, 30, Republic Ave., Temirtau, KazakhstanPolzunov Altai State Technical University, 46, Lenin Ave., Barnaul, Russian Federation The article is devoted to research on the synthesis of hydroxyquinoline derivative based on 8-oxyquinoline and maleic anhydride. Analysis of available literature was carried out, some drugs were found that are produced based on hydroxyquinoline derivatives and have antiprotozoal, antimicrobial and antiseptic effects, used alone or in combination with other active substances. A technique has been developed for the synthesis of a new derivative in the medium of petroleum distillate using sulfuric acid as a catalyst. A water-soluble ester of 8-oxyquinoline and maleic acid was obtained in good yield (95%), the structure of which was established based on UV, IR and NMR spectroscopy. By analogy with other oxyquinoline derivatives and the results of prediction bioactivity in the PASS program, the obtained derivative may be characterized by antifungal (antiseborrheic) action. It was determined its antibacterial properties at a concentration of 20.0–10.0 mg/cm3 as well as a significant antioxidant activity which is a useful biological property to expand the range of its application. https://ect-journal.kz/index.php/ectj/article/view/1148oxyquinolinemaleic anhydrideantimicrobial agentsNMR spectroscopy |
| spellingShingle | V.V. Merkulov A.I. Almazov S.K. Kabiyeva S.N. Mantler V.V. Konshin A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid Eurasian Chemico-Technological Journal oxyquinoline maleic anhydride antimicrobial agents NMR spectroscopy |
| title | A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid |
| title_full | A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid |
| title_fullStr | A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid |
| title_full_unstemmed | A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid |
| title_short | A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid |
| title_sort | simple procedure for synthesis of biological active 4 oxo 4 quinolin 8 yloxy but 2 enoic acid |
| topic | oxyquinoline maleic anhydride antimicrobial agents NMR spectroscopy |
| url | https://ect-journal.kz/index.php/ectj/article/view/1148 |
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