Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice
The relationship between intestinal microbiota and cognitive function has been investigated as one of the major topics within the intestinal microbiota–gut–brain axis. Although an increasing number of studies have demonstrated an improvement in learning and memory when using probiotics or prebiotics...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1164809/full |
| _version_ | 1797810605747339264 |
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| author | Kayo Ikuta Daisuke Joho Masaki Kakeyama Masaki Kakeyama Mitsuharu Matsumoto Mitsuharu Matsumoto |
| author_facet | Kayo Ikuta Daisuke Joho Masaki Kakeyama Masaki Kakeyama Mitsuharu Matsumoto Mitsuharu Matsumoto |
| author_sort | Kayo Ikuta |
| collection | DOAJ |
| description | The relationship between intestinal microbiota and cognitive function has been investigated as one of the major topics within the intestinal microbiota–gut–brain axis. Although an increasing number of studies have demonstrated an improvement in learning and memory when using probiotics or prebiotics, to date, there are no studies that target the cognitive flexibility observed in the early stages of several neuropsychiatric diseases, including dementia. We have recently developed a novel behavioral task using the touchscreen operant system to assess cognitive flexibility. We found that the disruption of the intestinal microbiota in mice induced a decline in cognitive flexibility. In the present study, we investigated the effects of treatments consisting of Bifidobacterium animalis subsp. lactis and arginine (Bifal + Arg), which promote the production of intestinal bacterial polyamine, on cognitive flexibility in the mouse model. Male C57BL6 mice orally treated with Bifal + Arg three times a week gradually decreased the 1st-choice incorrect diagonal rate with repeated reversals compared with the control group. Furthermore, in serial reversal phases, Bifal + Arg-treated mice shifted to the behavior of choosing a new correct spot more quickly after the reversal, and this was faster with repeated reversals. These results indicate that this treatment adapts to change and improves cognitive flexibility. This is the first report to show that intestinal environmental control, including probiotics and prebiotics, improves cognitive flexibility in mice. |
| first_indexed | 2024-03-13T07:11:21Z |
| format | Article |
| id | doaj.art-e874e7b2091e42b396e660b93024f264 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T07:11:21Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-e874e7b2091e42b396e660b93024f2642023-06-06T04:27:49ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.11648091164809Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in miceKayo Ikuta0Daisuke Joho1Masaki Kakeyama2Masaki Kakeyama3Mitsuharu Matsumoto4Mitsuharu Matsumoto5Dairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., Tokyo, JapanLaboratory for Environmental Brain Science, Faculty of Human Sciences, Waseda University, Tokorozawa, JapanLaboratory for Environmental Brain Science, Faculty of Human Sciences, Waseda University, Tokorozawa, JapanResearch Institute for Environmental Medical Sciences, Comprehensive Research Organization, Waseda University, Tokorozawa, JapanDairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., Tokyo, JapanResearch Institute for Environmental Medical Sciences, Comprehensive Research Organization, Waseda University, Tokorozawa, JapanThe relationship between intestinal microbiota and cognitive function has been investigated as one of the major topics within the intestinal microbiota–gut–brain axis. Although an increasing number of studies have demonstrated an improvement in learning and memory when using probiotics or prebiotics, to date, there are no studies that target the cognitive flexibility observed in the early stages of several neuropsychiatric diseases, including dementia. We have recently developed a novel behavioral task using the touchscreen operant system to assess cognitive flexibility. We found that the disruption of the intestinal microbiota in mice induced a decline in cognitive flexibility. In the present study, we investigated the effects of treatments consisting of Bifidobacterium animalis subsp. lactis and arginine (Bifal + Arg), which promote the production of intestinal bacterial polyamine, on cognitive flexibility in the mouse model. Male C57BL6 mice orally treated with Bifal + Arg three times a week gradually decreased the 1st-choice incorrect diagonal rate with repeated reversals compared with the control group. Furthermore, in serial reversal phases, Bifal + Arg-treated mice shifted to the behavior of choosing a new correct spot more quickly after the reversal, and this was faster with repeated reversals. These results indicate that this treatment adapts to change and improves cognitive flexibility. This is the first report to show that intestinal environmental control, including probiotics and prebiotics, improves cognitive flexibility in mice.https://www.frontiersin.org/articles/10.3389/fnut.2023.1164809/fulltouchscreen operant systemmicrobiota-gut-brain axisreversal learningpolyaminesfunctional foodlearning-set |
| spellingShingle | Kayo Ikuta Daisuke Joho Masaki Kakeyama Masaki Kakeyama Mitsuharu Matsumoto Mitsuharu Matsumoto Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice Frontiers in Nutrition touchscreen operant system microbiota-gut-brain axis reversal learning polyamines functional food learning-set |
| title | Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice |
| title_full | Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice |
| title_fullStr | Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice |
| title_full_unstemmed | Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice |
| title_short | Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice |
| title_sort | bifidobacterium animalis subsp lactis and arginine mixture intake improves cognitive flexibility in mice |
| topic | touchscreen operant system microbiota-gut-brain axis reversal learning polyamines functional food learning-set |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1164809/full |
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