Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population
<b>Background/Aim:</b> To investigate the possible association between the polymorphism of the <i> CTLA-4 </i> exon 1 +49 A/G and susceptibility to Crohn′s disease (CD) and ulcerative colitis (UC) in the Tunisian population. <b> Methods:</b>...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=1;spage=29;epage=34;aulast=Alaya |
| _version_ | 1819109172994637824 |
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| author | Alaya Walid Sfar Imen Aouadi Houda Jendoubi Saloua Najjar Tawfik Filali Azza Gorgi Yousr Abdallah Taieb Mouelhi Leila Matri Samira Ayed Khaled |
| author_facet | Alaya Walid Sfar Imen Aouadi Houda Jendoubi Saloua Najjar Tawfik Filali Azza Gorgi Yousr Abdallah Taieb Mouelhi Leila Matri Samira Ayed Khaled |
| author_sort | Alaya Walid |
| collection | DOAJ |
| description | <b>Background/Aim:</b> To investigate the possible association between the polymorphism of the <i> CTLA-4 </i> exon 1 +49 A/G and susceptibility to Crohn′s disease (CD) and ulcerative colitis (UC) in the Tunisian population. <b> Methods:</b> The +49 A/G dimorphism was analyzed in 119 patients with CD, 65 patients with UC, and 100 controls by the polymerase chain reaction-restriction fragment length polymorphism method. <b> Results:</b> Significantly higher frequencies of the <i> CTLA-4 </i> +49A allele and A/A homozygous individuals were observed in patients with CD when compared with controls (pc = 0.0023 and pc = 0.0003, respectively). Analysis of <i> CTLA-4</i> A/G polymorphism with respect to sex in CD showed a significant difference in A/A genotypes between female patients and controls (pc = 0.0001 and pc = 0.038, respectively). There were no differences in the subgroups of patients with CD. <b> Conclusions:</b> Forty-nine A alleles and AA genotype are associated with CD susceptibility in Tunisians. Other genes involved in the T-cell regulation remain strong candidates for IBD susceptibility and require further investigation. |
| first_indexed | 2024-12-22T03:21:37Z |
| format | Article |
| id | doaj.art-e87542fffb38470b9aff7798ab35720f |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-22T03:21:37Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-e87542fffb38470b9aff7798ab35720f2022-12-21T18:40:43ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492009-01-011512934Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian populationAlaya WalidSfar ImenAouadi HoudaJendoubi SalouaNajjar TawfikFilali AzzaGorgi YousrAbdallah TaiebMouelhi LeilaMatri SamiraAyed Khaled<b>Background/Aim:</b> To investigate the possible association between the polymorphism of the <i> CTLA-4 </i> exon 1 +49 A/G and susceptibility to Crohn′s disease (CD) and ulcerative colitis (UC) in the Tunisian population. <b> Methods:</b> The +49 A/G dimorphism was analyzed in 119 patients with CD, 65 patients with UC, and 100 controls by the polymerase chain reaction-restriction fragment length polymorphism method. <b> Results:</b> Significantly higher frequencies of the <i> CTLA-4 </i> +49A allele and A/A homozygous individuals were observed in patients with CD when compared with controls (pc = 0.0023 and pc = 0.0003, respectively). Analysis of <i> CTLA-4</i> A/G polymorphism with respect to sex in CD showed a significant difference in A/A genotypes between female patients and controls (pc = 0.0001 and pc = 0.038, respectively). There were no differences in the subgroups of patients with CD. <b> Conclusions:</b> Forty-nine A alleles and AA genotype are associated with CD susceptibility in Tunisians. Other genes involved in the T-cell regulation remain strong candidates for IBD susceptibility and require further investigation.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=1;spage=29;epage=34;aulast=AlayaCrohn′s disease<i> CTLA-4</i>gene polymorphisminflammatory bowel diseaseulcerative colitis |
| spellingShingle | Alaya Walid Sfar Imen Aouadi Houda Jendoubi Saloua Najjar Tawfik Filali Azza Gorgi Yousr Abdallah Taieb Mouelhi Leila Matri Samira Ayed Khaled Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population The Saudi Journal of Gastroenterology Crohn′s disease <i> CTLA-4</i> gene polymorphism inflammatory bowel disease ulcerative colitis |
| title | Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population |
| title_full | Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population |
| title_fullStr | Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population |
| title_full_unstemmed | Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population |
| title_short | Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population |
| title_sort | association between ctla 4 gene promoter 49 a g in exon 1 polymorphisms and inflammatory bowel disease in the tunisian population |
| topic | Crohn′s disease <i> CTLA-4</i> gene polymorphism inflammatory bowel disease ulcerative colitis |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=1;spage=29;epage=34;aulast=Alaya |
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