A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis
Magnesium (Mg<sup>2+</sup>) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg<sup>2+</sup> intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, dif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/19/7084 |
| _version_ | 1797552587405262848 |
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| author | Fabiana da Silva Lima Ricardo Ambrósio Fock |
| author_facet | Fabiana da Silva Lima Ricardo Ambrósio Fock |
| author_sort | Fabiana da Silva Lima |
| collection | DOAJ |
| description | Magnesium (Mg<sup>2+</sup>) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg<sup>2+</sup> intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg<sup>2+</sup> deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg<sup>2+</sup> has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg<sup>2+</sup> homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg<sup>2+</sup> on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg<sup>2+</sup> homeostasis can have on hematopoietic cells and hematopoietic tissue. |
| first_indexed | 2024-03-10T16:03:12Z |
| format | Article |
| id | doaj.art-e875b90727a84d63be8a289b2571d9e6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:03:12Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e875b90727a84d63be8a289b2571d9e62023-11-20T15:08:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012119708410.3390/ijms21197084A Review of the Action of Magnesium on Several Processes Involved in the Modulation of HematopoiesisFabiana da Silva Lima0Ricardo Ambrósio Fock1Department of Food and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, BrazilLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Avenida Lineu Prestes, 580-Bloco 17, São Paulo 05508-000, BrazilMagnesium (Mg<sup>2+</sup>) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg<sup>2+</sup> intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg<sup>2+</sup> deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg<sup>2+</sup> has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg<sup>2+</sup> homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg<sup>2+</sup> on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg<sup>2+</sup> homeostasis can have on hematopoietic cells and hematopoietic tissue.https://www.mdpi.com/1422-0067/21/19/7084magnesiumhematopoietic tissuehematopoietic cellsbone marrowimmune cells |
| spellingShingle | Fabiana da Silva Lima Ricardo Ambrósio Fock A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis International Journal of Molecular Sciences magnesium hematopoietic tissue hematopoietic cells bone marrow immune cells |
| title | A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis |
| title_full | A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis |
| title_fullStr | A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis |
| title_full_unstemmed | A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis |
| title_short | A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis |
| title_sort | review of the action of magnesium on several processes involved in the modulation of hematopoiesis |
| topic | magnesium hematopoietic tissue hematopoietic cells bone marrow immune cells |
| url | https://www.mdpi.com/1422-0067/21/19/7084 |
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