Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis
BackgroundPrevious epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) an...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157313/full |
| _version_ | 1797799597044662272 |
|---|---|
| author | Wen Cheng Wen Cheng Yang Liao Yang Liao Ruiyu Mou Ruiyu Mou Xian Xiao Xian Xiao Yingjie Jia Yingjie Jia |
| author_facet | Wen Cheng Wen Cheng Yang Liao Yang Liao Ruiyu Mou Ruiyu Mou Xian Xiao Xian Xiao Yingjie Jia Yingjie Jia |
| author_sort | Wen Cheng |
| collection | DOAJ |
| description | BackgroundPrevious epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis.MethodsWe performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.ResultsGenetically determined IBD did not have a causal effect on PCa (IVW P > 0.05). Additionally, there was no causal effect of Crohn’s disease (CD) and ulcerative colitis (UC) on PCa in the MR analysis (IVW P > 0.05). Results of complementary methods were consistent with those of the IVW method.ConclusionsThis study does not support a causal association of IBD on PCa, which is in contrast to most observational studies. |
| first_indexed | 2024-03-13T04:21:17Z |
| format | Article |
| id | doaj.art-e877aa9f54de433989603a208cf803ec |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T04:21:17Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e877aa9f54de433989603a208cf803ec2023-06-20T10:09:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11573131157313Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysisWen Cheng0Wen Cheng1Yang Liao2Yang Liao3Ruiyu Mou4Ruiyu Mou5Xian Xiao6Xian Xiao7Yingjie Jia8Yingjie Jia9Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaBackgroundPrevious epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis.MethodsWe performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.ResultsGenetically determined IBD did not have a causal effect on PCa (IVW P > 0.05). Additionally, there was no causal effect of Crohn’s disease (CD) and ulcerative colitis (UC) on PCa in the MR analysis (IVW P > 0.05). Results of complementary methods were consistent with those of the IVW method.ConclusionsThis study does not support a causal association of IBD on PCa, which is in contrast to most observational studies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157313/fullinflammatory bowel diseaseprostate cancerMendelian randomizationcausalityCrohn ‘s diseaseulcerative colitis |
| spellingShingle | Wen Cheng Wen Cheng Yang Liao Yang Liao Ruiyu Mou Ruiyu Mou Xian Xiao Xian Xiao Yingjie Jia Yingjie Jia Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis Frontiers in Immunology inflammatory bowel disease prostate cancer Mendelian randomization causality Crohn ‘s disease ulcerative colitis |
| title | Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis |
| title_full | Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis |
| title_fullStr | Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis |
| title_full_unstemmed | Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis |
| title_short | Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis |
| title_sort | inflammatory bowel disease and prostate cancer risk a two sample mendelian randomization analysis |
| topic | inflammatory bowel disease prostate cancer Mendelian randomization causality Crohn ‘s disease ulcerative colitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157313/full |
| work_keys_str_mv | AT wencheng inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT wencheng inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT yangliao inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT yangliao inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT ruiyumou inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT ruiyumou inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT xianxiao inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT xianxiao inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT yingjiejia inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis AT yingjiejia inflammatoryboweldiseaseandprostatecancerriskatwosamplemendelianrandomizationanalysis |