Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery
Abstract Right ventricular failure (RVF) after cardiac surgery is associated with an in-hospital mortality rate of up to 75%. Microaxial flow pumps are one of the mechanical circulatory supports (MCS) options available for the treatment of RVF, however the specifics of timing and indication for MCS,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-58602-w |
| _version_ | 1797219832644501504 |
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| author | Medina Marta Mahmoud Zada Nils Theuerkauf Georg Daniel Duerr Sebastian Zimmer Hendrik Treede Mehmet Oezkur |
| author_facet | Medina Marta Mahmoud Zada Nils Theuerkauf Georg Daniel Duerr Sebastian Zimmer Hendrik Treede Mehmet Oezkur |
| author_sort | Medina Marta |
| collection | DOAJ |
| description | Abstract Right ventricular failure (RVF) after cardiac surgery is associated with an in-hospital mortality rate of up to 75%. Microaxial flow pumps are one of the mechanical circulatory supports (MCS) options available for the treatment of RVF, however the specifics of timing and indication for MCS, as well as predictors for survival, remain unclear due to a dearth of published data. We evaluated the clinical outcome of patients treated with Impella-RP for predictors of mortality and the hemodynamic effects of the pump. This is a single-center retrospective observational study involving adult patients who underwent cardiac surgery with cardiopulmonary bypass between January 2019 and December 2020 in cardiac surgery and required therapeutic management of RVF with an Impella-RP. Overall, 18 patients were included and analyzed for factors that could be associated with mortality, or that could be predictors of patient outcomes for this population. Treatment of RVF with Impella-RP improved the patient hemodynamics significantly and had a survival rate of 61% within 30 days. Patients with isolated CABG or better liver function before implantation had a better survival rate, which may indicate that underlying disease and timing of implantation are significant for successful treatment of RVF. |
| first_indexed | 2024-04-24T12:39:55Z |
| format | Article |
| id | doaj.art-e877f74dc9d6473e904b0a24d353d9bd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T12:39:55Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e877f74dc9d6473e904b0a24d353d9bd2024-04-07T11:18:11ZengNature PortfolioScientific Reports2045-23222024-04-011411810.1038/s41598-024-58602-wOutcome of right ventricular microaxial pump support in patients undergoing cardiac surgeryMedina Marta0Mahmoud Zada1Nils Theuerkauf2Georg Daniel Duerr3Sebastian Zimmer4Hendrik Treede5Mehmet Oezkur6Department of Cardiovasular Surgery, University Hospital of Mainz, University Medical Center of the Johannes Gutenberg University MainzDepartment of Cardiology and Rhythmology, Hospital MechernichDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of BonnDepartment of Cardiovasular Surgery, University Hospital of Mainz, University Medical Center of the Johannes Gutenberg University MainzDepartment of Cardiology, University Hospital of BonnDepartment of Cardiovasular Surgery, University Hospital of Mainz, University Medical Center of the Johannes Gutenberg University MainzDepartment of Cardiovasular Surgery, University Hospital of Mainz, University Medical Center of the Johannes Gutenberg University MainzAbstract Right ventricular failure (RVF) after cardiac surgery is associated with an in-hospital mortality rate of up to 75%. Microaxial flow pumps are one of the mechanical circulatory supports (MCS) options available for the treatment of RVF, however the specifics of timing and indication for MCS, as well as predictors for survival, remain unclear due to a dearth of published data. We evaluated the clinical outcome of patients treated with Impella-RP for predictors of mortality and the hemodynamic effects of the pump. This is a single-center retrospective observational study involving adult patients who underwent cardiac surgery with cardiopulmonary bypass between January 2019 and December 2020 in cardiac surgery and required therapeutic management of RVF with an Impella-RP. Overall, 18 patients were included and analyzed for factors that could be associated with mortality, or that could be predictors of patient outcomes for this population. Treatment of RVF with Impella-RP improved the patient hemodynamics significantly and had a survival rate of 61% within 30 days. Patients with isolated CABG or better liver function before implantation had a better survival rate, which may indicate that underlying disease and timing of implantation are significant for successful treatment of RVF.https://doi.org/10.1038/s41598-024-58602-w |
| spellingShingle | Medina Marta Mahmoud Zada Nils Theuerkauf Georg Daniel Duerr Sebastian Zimmer Hendrik Treede Mehmet Oezkur Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery Scientific Reports |
| title | Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| title_full | Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| title_fullStr | Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| title_full_unstemmed | Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| title_short | Outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| title_sort | outcome of right ventricular microaxial pump support in patients undergoing cardiac surgery |
| url | https://doi.org/10.1038/s41598-024-58602-w |
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