Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest
Patients with chronic pain due to neuropathy or musculoskeletal injury frequently exhibit reduced alpha and increased theta power densities. However, little is known about electrical brain activity and chronic pain in patients with rheumatoid arthritis (RA). For this purpose, we evaluated power den...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00395/full |
| _version_ | 1819104566064447488 |
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| author | Francisco M Meneses Francisco M Meneses Fernanda Costa Queiros Pedro Montoya José Garcia Vivas Miranda Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Katia Nunes Sá Katia Nunes Sá Cleber Luz-Santos Abrahão Fontes Baptista Abrahão Fontes Baptista Abrahão Fontes Baptista |
| author_facet | Francisco M Meneses Francisco M Meneses Fernanda Costa Queiros Pedro Montoya José Garcia Vivas Miranda Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Katia Nunes Sá Katia Nunes Sá Cleber Luz-Santos Abrahão Fontes Baptista Abrahão Fontes Baptista Abrahão Fontes Baptista |
| author_sort | Francisco M Meneses |
| collection | DOAJ |
| description | Patients with chronic pain due to neuropathy or musculoskeletal injury frequently exhibit reduced alpha and increased theta power densities. However, little is known about electrical brain activity and chronic pain in patients with rheumatoid arthritis (RA). For this purpose, we evaluated power densities of spontaneous electroencephalogram (EEG) band frequencies (delta, theta, alpha, and beta) in females with persistent pain due to RA. This was a cross-sectional study of 21 participants with RA and 21 healthy controls (mean age = 47.20; SD = 10.40). EEG was recorded at rest over five minutes with participant's eyes closed. Twenty electrodes were placed over five brain regions (frontal, central, parietal, temporal, and occipital). Significant differences were observed in depression and anxiety with higher scores in RA participants than healthy controls (p = .002). Participants with RA exhibited increased average absolute alpha power density in all brain regions when compared to controls (F (1.39) = 6.39, p = .016), as well as increased average relative alpha power density (F (1.39) = 5.82, p = .021) in all regions, except the frontal region, controlling for depression/anxiety. Absolute theta power density also increased in the frontal, central, and parietal regions for participants with RA when compared to controls (F(1,39) = 4.51, p = .040), controlling for depression/anxiety. Differences were not exhibited on beta and delta absolute and relative power densities. The diffuse increased alpha may suggest a possible neurogenic mechanism for chronic pain in individuals with RA. |
| first_indexed | 2024-12-22T02:08:23Z |
| format | Article |
| id | doaj.art-e8784de97c6b4c1eb0f95c3c02f09b18 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T02:08:23Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-e8784de97c6b4c1eb0f95c3c02f09b182022-12-21T18:42:28ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-08-011010.3389/fnhum.2016.00395181310Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at RestFrancisco M Meneses0Francisco M Meneses1Fernanda Costa Queiros2Pedro Montoya3José Garcia Vivas Miranda4Selena Márcia Dubois-Mendes5Selena Márcia Dubois-Mendes6Selena Márcia Dubois-Mendes7Katia Nunes Sá8Katia Nunes Sá9Cleber Luz-Santos10Abrahão Fontes Baptista11Abrahão Fontes Baptista12Abrahão Fontes Baptista13Federal University of BahiaFederal University of BahiaFederal University of BahiaUniversity of Balearic IslandsFederal University of BahiaFederal University of BahiaFederal University of BahiaBahia School of Medicine and Public HealthFederal University of BahiaBahia School of Medicine and Public HealthFederal University of BahiaFederal University of BahiaFederal University of BahiaBahia School of Medicine and Public HealthPatients with chronic pain due to neuropathy or musculoskeletal injury frequently exhibit reduced alpha and increased theta power densities. However, little is known about electrical brain activity and chronic pain in patients with rheumatoid arthritis (RA). For this purpose, we evaluated power densities of spontaneous electroencephalogram (EEG) band frequencies (delta, theta, alpha, and beta) in females with persistent pain due to RA. This was a cross-sectional study of 21 participants with RA and 21 healthy controls (mean age = 47.20; SD = 10.40). EEG was recorded at rest over five minutes with participant's eyes closed. Twenty electrodes were placed over five brain regions (frontal, central, parietal, temporal, and occipital). Significant differences were observed in depression and anxiety with higher scores in RA participants than healthy controls (p = .002). Participants with RA exhibited increased average absolute alpha power density in all brain regions when compared to controls (F (1.39) = 6.39, p = .016), as well as increased average relative alpha power density (F (1.39) = 5.82, p = .021) in all regions, except the frontal region, controlling for depression/anxiety. Absolute theta power density also increased in the frontal, central, and parietal regions for participants with RA when compared to controls (F(1,39) = 4.51, p = .040), controlling for depression/anxiety. Differences were not exhibited on beta and delta absolute and relative power densities. The diffuse increased alpha may suggest a possible neurogenic mechanism for chronic pain in individuals with RA.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00395/fullAlpha RhythmBeta RhythmChronic PainDelta RhythmTheta RhythmEEG |
| spellingShingle | Francisco M Meneses Francisco M Meneses Fernanda Costa Queiros Pedro Montoya José Garcia Vivas Miranda Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Selena Márcia Dubois-Mendes Katia Nunes Sá Katia Nunes Sá Cleber Luz-Santos Abrahão Fontes Baptista Abrahão Fontes Baptista Abrahão Fontes Baptista Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest Frontiers in Human Neuroscience Alpha Rhythm Beta Rhythm Chronic Pain Delta Rhythm Theta Rhythm EEG |
| title | Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest |
| title_full | Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest |
| title_fullStr | Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest |
| title_full_unstemmed | Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest |
| title_short | Patients with Rheumatoid Arthritis and Chronic Pain Display Enhanced Alpha Power Density at Rest |
| title_sort | patients with rheumatoid arthritis and chronic pain display enhanced alpha power density at rest |
| topic | Alpha Rhythm Beta Rhythm Chronic Pain Delta Rhythm Theta Rhythm EEG |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00395/full |
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