A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny

A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny

Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis of fetal and adult neutrophils, we shed new light...

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Bibliographic Details
Main Authors: Ina Rohwedder, Lou Martha Wackerbarth, Kristina Heinig, Annamaria Ballweg, Johannes Altstätter, Myriam Ripphahn, Claudia Nussbaum, Melanie Salvermoser, Susanne Bierschenk, Tobias Straub, Matthias Gunzer, Marc Schmidt-Supprian, Thomas Kolben, Christian Schulz, Averil Ma, Barbara Walzog, Matthias Heinig, Markus Sperandio
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-02-01
Series:JCI Insight
Subjects:
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.155968

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