Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study
BackgroundMany observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality and confounding factors, and there is no definite causal study between unsaturated fatty acids and psoriasis.ObjectivesAnalysis of causality between unsa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1280962/full |
| _version_ | 1797319519188811776 |
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| author | Junchen Li Qian Shen Chenqi Guo Yingdong Wang Yuxiao Ma Yu Zhang |
| author_facet | Junchen Li Qian Shen Chenqi Guo Yingdong Wang Yuxiao Ma Yu Zhang |
| author_sort | Junchen Li |
| collection | DOAJ |
| description | BackgroundMany observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality and confounding factors, and there is no definite causal study between unsaturated fatty acids and psoriasis.ObjectivesAnalysis of causality between unsaturated fatty acids and psoriasis by Mendelian randomization.MethodsWe used IEU Open GWAS Project, omega-3 PUFA and omega-6 PUFA data from 114,999 subjects, MUFA data from 13,535 subjects, and psoriasis data from 4,510 cases and 212,242 controls were included. We employed the inverse-variance weighted (IVW) method as the primary analytical approach and four additional MR methods. Moreover, we performed heterogeneity and horizontal pleiotropy assessments using Cochrane’s Q and MR-Egger intercept tests, respectively. Finally, we performed sensitivity analyses to enhance our findings’ precision and veracity.ResultsIVW results showed no causal effect of omega-3 PUFA on psoriasis (p = 0.334; OR, 0.909; 95% CI, 0.748–1.104), omega-6 PUFA cause psoriasis (p = 0.046; OR, 1.174; 95% CI, 1.003–1.374), MUFA cause psoriasis (p = 0.032; OR, 1.218; 95% CI, 1.018–1.457), no causal effect of omega-3 PUFA in psoriasis (p = 0.695; OR, 0.989; 95% CI, 0.937–1.044), no causal effect of omega-6 PUFA in psoriasis (p = 0.643; OR, 1.013; 95% CI, 0.960–1.068), psoriasis is not causal to MUFA (p = 0.986; OR, 1.000; 95% CI, 0.949–1.055). Heterogeneity, horizontal pleiotropy, and sensitivity analyses showed reliable results.ConclusionWe found that circulating omega-6 PUFA and MUFA cause psoriasis, while omega-3 PUFA do not. Treatments that lower circulating omega-6 PUFA and MUFA are effective in psoriasis. After a better understanding of fatty acid intake and circulation, the population can be advised to regulate their diet. |
| first_indexed | 2024-03-08T04:08:03Z |
| format | Article |
| id | doaj.art-e87c8f027430460a8bb8ecdb2558bb31 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-08T04:08:03Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-e87c8f027430460a8bb8ecdb2558bb312024-02-09T04:25:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-02-011110.3389/fnut.2024.12809621280962Causality of unsaturated fatty acids and psoriasis a Mendelian randomization studyJunchen Li0Qian Shen1Chenqi Guo2Yingdong Wang3Yuxiao Ma4Yu Zhang5Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDermatology Department, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDermatology Department, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaBackgroundMany observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality and confounding factors, and there is no definite causal study between unsaturated fatty acids and psoriasis.ObjectivesAnalysis of causality between unsaturated fatty acids and psoriasis by Mendelian randomization.MethodsWe used IEU Open GWAS Project, omega-3 PUFA and omega-6 PUFA data from 114,999 subjects, MUFA data from 13,535 subjects, and psoriasis data from 4,510 cases and 212,242 controls were included. We employed the inverse-variance weighted (IVW) method as the primary analytical approach and four additional MR methods. Moreover, we performed heterogeneity and horizontal pleiotropy assessments using Cochrane’s Q and MR-Egger intercept tests, respectively. Finally, we performed sensitivity analyses to enhance our findings’ precision and veracity.ResultsIVW results showed no causal effect of omega-3 PUFA on psoriasis (p = 0.334; OR, 0.909; 95% CI, 0.748–1.104), omega-6 PUFA cause psoriasis (p = 0.046; OR, 1.174; 95% CI, 1.003–1.374), MUFA cause psoriasis (p = 0.032; OR, 1.218; 95% CI, 1.018–1.457), no causal effect of omega-3 PUFA in psoriasis (p = 0.695; OR, 0.989; 95% CI, 0.937–1.044), no causal effect of omega-6 PUFA in psoriasis (p = 0.643; OR, 1.013; 95% CI, 0.960–1.068), psoriasis is not causal to MUFA (p = 0.986; OR, 1.000; 95% CI, 0.949–1.055). Heterogeneity, horizontal pleiotropy, and sensitivity analyses showed reliable results.ConclusionWe found that circulating omega-6 PUFA and MUFA cause psoriasis, while omega-3 PUFA do not. Treatments that lower circulating omega-6 PUFA and MUFA are effective in psoriasis. After a better understanding of fatty acid intake and circulation, the population can be advised to regulate their diet.https://www.frontiersin.org/articles/10.3389/fnut.2024.1280962/fullpsoriasispolyunsaturated fatty acidsomega-3omega-6monounsaturated fatty acidsMendelian randomization |
| spellingShingle | Junchen Li Qian Shen Chenqi Guo Yingdong Wang Yuxiao Ma Yu Zhang Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study Frontiers in Nutrition psoriasis polyunsaturated fatty acids omega-3 omega-6 monounsaturated fatty acids Mendelian randomization |
| title | Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study |
| title_full | Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study |
| title_fullStr | Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study |
| title_full_unstemmed | Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study |
| title_short | Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study |
| title_sort | causality of unsaturated fatty acids and psoriasis a mendelian randomization study |
| topic | psoriasis polyunsaturated fatty acids omega-3 omega-6 monounsaturated fatty acids Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1280962/full |
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