Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults
Abstract In the sulfotransferase (SULT) superfamily, members of the SULT1 family mainly catalyse the sulfonation reaction of phenolic compounds, which is involved in the phase II metabolic detoxification process and plays a key role in endocrine homeostasis. A coding variant rs1059491 in the SULT1A2...
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34296-4 |
| _version_ | 1797811580183773184 |
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| author | Hai-Yan Lv Guifeng Shi Cai Li Ya-Fei Ye Ya-Hong Chen Li-Hua Chen Tao-Hsin Tung Meixian Zhang |
| author_facet | Hai-Yan Lv Guifeng Shi Cai Li Ya-Fei Ye Ya-Hong Chen Li-Hua Chen Tao-Hsin Tung Meixian Zhang |
| author_sort | Hai-Yan Lv |
| collection | DOAJ |
| description | Abstract In the sulfotransferase (SULT) superfamily, members of the SULT1 family mainly catalyse the sulfonation reaction of phenolic compounds, which is involved in the phase II metabolic detoxification process and plays a key role in endocrine homeostasis. A coding variant rs1059491 in the SULT1A2 gene has been reported to be associated with childhood obesity. This study aimed to investigate the association of rs1059491 with the risk of obesity and cardiometabolic abnormalities in adults. This case‒control study included 226 normal weight, 168 overweight and 72 obese adults who underwent a health examination in Taizhou, China. Genotyping of rs1059491 was performed by Sanger sequencing in exon 7 of the SULT1A2 coding region. Chi-squared tests, one-way ANOVA, and logistic regression models were applied. The minor allele frequencies of rs1059491 in the overweight combined with obesity and control groups were 0.0292 and 0.0686, respectively. No differences in weight and body mass index were detected between the TT genotype and GT + GG genotype under the dominant model, but the levels of serum triglycerides were significantly lower in G-allele carriers than in non-G-allele carriers (1.02 (0.74–1.32) vs. 1.35 (0.83–2.13) mmol/L, P = 0.011). The GT + GG genotype of rs1059491 versus the TT genotype reduced the risk of overweight and obesity by 54% (OR 0.46, 95% CI 0.22–0.96, P = 0.037) after adjusting for sex and age. Similar results were observed for hypertriglyceridaemia (OR 0.25, 95% CI 0.08–0.74, P = 0.013) and dyslipidaemia (OR 0.37, 95% CI 0.17–0.83, P = 0.015). However, these associations disappeared after correction for multiple tests. This study revealed that the coding variant rs1059491 is nominally associated with a decreased risk of obesity and dyslipidaemia in southern Chinese adults. The findings will be validated in larger studies including more detailed information on genetic background, lifestyle and weight change with age. |
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| id | doaj.art-e87d938377cf44febdfe5d670544a4c6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T07:24:49Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-e87d938377cf44febdfe5d670544a4c62023-06-04T11:26:30ZengNature PortfolioScientific Reports2045-23222023-05-011311710.1038/s41598-023-34296-4Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adultsHai-Yan Lv0Guifeng Shi1Cai Li2Ya-Fei Ye3Ya-Hong Chen4Li-Hua Chen5Tao-Hsin Tung6Meixian Zhang7Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityDepartment of Preventive Health Care, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityDepartment of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityHealth Management Centre, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityHealth Management Centre, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityPublic Scientific Research Platform, Taizhou Hospital of Zhejiang Province Affiliated To Wenzhou Medical UniversityEvidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityEvidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityAbstract In the sulfotransferase (SULT) superfamily, members of the SULT1 family mainly catalyse the sulfonation reaction of phenolic compounds, which is involved in the phase II metabolic detoxification process and plays a key role in endocrine homeostasis. A coding variant rs1059491 in the SULT1A2 gene has been reported to be associated with childhood obesity. This study aimed to investigate the association of rs1059491 with the risk of obesity and cardiometabolic abnormalities in adults. This case‒control study included 226 normal weight, 168 overweight and 72 obese adults who underwent a health examination in Taizhou, China. Genotyping of rs1059491 was performed by Sanger sequencing in exon 7 of the SULT1A2 coding region. Chi-squared tests, one-way ANOVA, and logistic regression models were applied. The minor allele frequencies of rs1059491 in the overweight combined with obesity and control groups were 0.0292 and 0.0686, respectively. No differences in weight and body mass index were detected between the TT genotype and GT + GG genotype under the dominant model, but the levels of serum triglycerides were significantly lower in G-allele carriers than in non-G-allele carriers (1.02 (0.74–1.32) vs. 1.35 (0.83–2.13) mmol/L, P = 0.011). The GT + GG genotype of rs1059491 versus the TT genotype reduced the risk of overweight and obesity by 54% (OR 0.46, 95% CI 0.22–0.96, P = 0.037) after adjusting for sex and age. Similar results were observed for hypertriglyceridaemia (OR 0.25, 95% CI 0.08–0.74, P = 0.013) and dyslipidaemia (OR 0.37, 95% CI 0.17–0.83, P = 0.015). However, these associations disappeared after correction for multiple tests. This study revealed that the coding variant rs1059491 is nominally associated with a decreased risk of obesity and dyslipidaemia in southern Chinese adults. The findings will be validated in larger studies including more detailed information on genetic background, lifestyle and weight change with age.https://doi.org/10.1038/s41598-023-34296-4 |
| spellingShingle | Hai-Yan Lv Guifeng Shi Cai Li Ya-Fei Ye Ya-Hong Chen Li-Hua Chen Tao-Hsin Tung Meixian Zhang Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults Scientific Reports |
| title | Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults |
| title_full | Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults |
| title_fullStr | Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults |
| title_full_unstemmed | Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults |
| title_short | Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults |
| title_sort | association of sult1a2 rs1059491 with obesity and dyslipidaemia in southern chinese adults |
| url | https://doi.org/10.1038/s41598-023-34296-4 |
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