Gold Nanoclusters for Tumor Diagnosis and Treatment
Nanomedicine shows remarkable potential to improve the efficacy of diagnosis and treatment of tumors, utilizing nanotechnologies and nanomaterials. Gold nanoclusters (AuNCs) have emerged as a highly promising option due to their exceptional optical and enzyme‐mimicking catalytic activities as well a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-12-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300082 |
| _version_ | 1797392227163439104 |
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| author | Shiqun Chen Shasha Li Yili Wang Zuohong Chen Hao Wang Xiao-Dong Zhang |
| author_facet | Shiqun Chen Shasha Li Yili Wang Zuohong Chen Hao Wang Xiao-Dong Zhang |
| author_sort | Shiqun Chen |
| collection | DOAJ |
| description | Nanomedicine shows remarkable potential to improve the efficacy of diagnosis and treatment of tumors, utilizing nanotechnologies and nanomaterials. Gold nanoclusters (AuNCs) have emerged as a highly promising option due to their exceptional optical and enzyme‐mimicking catalytic activities as well as good biocompatibility. The renal clearable clusters can enrich in the tumors upon their enhanced permeability and retention properties, which benefits the tumor‐related applications. The fluorescence of AuNCs in the second near‐infrared region possesses extraordinary penetration depth and high temporal–spatial resolution, enabling excellent in vivo imaging and real‐time monitoring of pathological process. AuNC‐based nanoplatforms represent a paradigm of integrated, efficient, intelligent, and safe treatment strategy, extending personalized tumor therapy. Meanwhile, the optical and biocatalytic properties can be modulated by adopting the atom/ligand engineering, which further enhances the efficacy of AuNCs. Herein, the advances of AuNCs in the field of diagnosis and treatment of tumors are summarized and the directions to be improved are proposed to promote the clinical translation of the AuNCs. |
| first_indexed | 2024-03-08T23:44:11Z |
| format | Article |
| id | doaj.art-e87e31ed418c4d229399e18d4d614861 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-08T23:44:11Z |
| publishDate | 2023-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-e87e31ed418c4d229399e18d4d6148612023-12-14T03:55:56ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-12-01312n/an/a10.1002/anbr.202300082Gold Nanoclusters for Tumor Diagnosis and TreatmentShiqun Chen0Shasha Li1Yili Wang2Zuohong Chen3Hao Wang4Xiao-Dong Zhang5Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaTianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaTianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaTianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaTianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaTianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 ChinaNanomedicine shows remarkable potential to improve the efficacy of diagnosis and treatment of tumors, utilizing nanotechnologies and nanomaterials. Gold nanoclusters (AuNCs) have emerged as a highly promising option due to their exceptional optical and enzyme‐mimicking catalytic activities as well as good biocompatibility. The renal clearable clusters can enrich in the tumors upon their enhanced permeability and retention properties, which benefits the tumor‐related applications. The fluorescence of AuNCs in the second near‐infrared region possesses extraordinary penetration depth and high temporal–spatial resolution, enabling excellent in vivo imaging and real‐time monitoring of pathological process. AuNC‐based nanoplatforms represent a paradigm of integrated, efficient, intelligent, and safe treatment strategy, extending personalized tumor therapy. Meanwhile, the optical and biocatalytic properties can be modulated by adopting the atom/ligand engineering, which further enhances the efficacy of AuNCs. Herein, the advances of AuNCs in the field of diagnosis and treatment of tumors are summarized and the directions to be improved are proposed to promote the clinical translation of the AuNCs.https://doi.org/10.1002/anbr.202300082diagnosesgold nanoclustersNIR-II imagingstreatmentstumors |
| spellingShingle | Shiqun Chen Shasha Li Yili Wang Zuohong Chen Hao Wang Xiao-Dong Zhang Gold Nanoclusters for Tumor Diagnosis and Treatment Advanced NanoBiomed Research diagnoses gold nanoclusters NIR-II imagings treatments tumors |
| title | Gold Nanoclusters for Tumor Diagnosis and Treatment |
| title_full | Gold Nanoclusters for Tumor Diagnosis and Treatment |
| title_fullStr | Gold Nanoclusters for Tumor Diagnosis and Treatment |
| title_full_unstemmed | Gold Nanoclusters for Tumor Diagnosis and Treatment |
| title_short | Gold Nanoclusters for Tumor Diagnosis and Treatment |
| title_sort | gold nanoclusters for tumor diagnosis and treatment |
| topic | diagnoses gold nanoclusters NIR-II imagings treatments tumors |
| url | https://doi.org/10.1002/anbr.202300082 |
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