1-(2,5-Dimethoxy-4-nitrophenyl)piperidine
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (<b>2b</b>) in 15% yield. Yields of nucleophilic aromatic substitution ad...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2023/4/M1744 |
| Summary: | Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (<b>2b</b>) in 15% yield. Yields of nucleophilic aromatic substitution adducts are high when using purified 1,4-dimethoxy-2,5-dinitrobenzene (<b>1b</b>) with piperidine and pyrrolidine to give (<b>2b</b>) and 1-(2,5-dimethoxy-4-nitrophenyl)pyrrolidine (<b>3b</b>) in 76% and 82% yield, respectively. |
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| ISSN: | 1422-8599 |