Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites

Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites

Gasdermins (GSDMs) are a group of proteins that are cleaved by inflammatory caspases to induce pore formation in the plasma membrane to cause membrane permeabilization and lytic cell death or pyroptosis. All GSDMs share a conserved structure, containing a cytotoxic N-terminal (NT) pore-forming domai...

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Bibliographic Details
Main Authors: Shanshan Wang, France Moreau, Kris Chadee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
gasdermin
parasite
macrophage
Entamoba histolytica
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.900553/full

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