Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction
Abstract The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202204594 |
| _version_ | 1797860851230703616 |
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| author | Wenyan Xie Xi Wei Heemin Kang Hong Jiang Zhiqin Chu Yuan Lin Yong Hou Qiang Wei |
| author_facet | Wenyan Xie Xi Wei Heemin Kang Hong Jiang Zhiqin Chu Yuan Lin Yong Hou Qiang Wei |
| author_sort | Wenyan Xie |
| collection | DOAJ |
| description | Abstract The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state‐of‐the‐art manipulation techniques and novel materials in designing static and dynamic ECM‐mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected. |
| first_indexed | 2024-04-09T21:52:33Z |
| format | Article |
| id | doaj.art-e880ef2b9a684112ab51b42c2498e71a |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T21:52:33Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-e880ef2b9a684112ab51b42c2498e71a2023-03-24T12:30:04ZengWileyAdvanced Science2198-38442023-03-01109n/an/a10.1002/advs.202204594Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular MechanotransductionWenyan Xie0Xi Wei1Heemin Kang2Hong Jiang3Zhiqin Chu4Yuan Lin5Yong Hou6Qiang Wei7Department of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan 610065 ChinaDepartment of Mechanical Engineering The University of Hong Kong Hong Kong ChinaDepartment of Materials Science and Engineering Korea University Seoul 02841 South KoreaDepartment of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan 610065 ChinaDepartment of Electrical and Electronic Engineering (Joint Appointment with School of Biomedical Sciences) The University of Hong Kong Hong Kong ChinaDepartment of Mechanical Engineering The University of Hong Kong Hong Kong ChinaDepartment of Electrical and Electronic Engineering The University of Hong Kong Hong Kong ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials and Engineering Sichuan University Chengdu 610065 ChinaAbstract The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state‐of‐the‐art manipulation techniques and novel materials in designing static and dynamic ECM‐mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected.https://doi.org/10.1002/advs.202204594cellular forceECM dynamicsengineering biomaterialsmatrix mechanicsmechanotransduction |
| spellingShingle | Wenyan Xie Xi Wei Heemin Kang Hong Jiang Zhiqin Chu Yuan Lin Yong Hou Qiang Wei Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction Advanced Science cellular force ECM dynamics engineering biomaterials matrix mechanics mechanotransduction |
| title | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
| title_full | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
| title_fullStr | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
| title_full_unstemmed | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
| title_short | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
| title_sort | static and dynamic evolving biomaterial mechanical properties to control cellular mechanotransduction |
| topic | cellular force ECM dynamics engineering biomaterials matrix mechanics mechanotransduction |
| url | https://doi.org/10.1002/advs.202204594 |
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