Changes in central adipose tissue after switching to integrase inhibitors
Background: Treatment with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain, however the long-term effect of INSTI-based regimens on adipose tissue (AT) compartments remains unknown. Objectives: To evaluate the effect of switching to an INSTI on visceral (VAT...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-11-01
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| Series: | HIV Research & Clinical Practice |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/25787489.2020.1848131 |
| _version_ | 1827794889727803392 |
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| author | Paula Debroy Han Feng Hongyu Miao Jovana Milic Guido Ligabue Stefano Draisci Giulia Besutti Federica Carli Marianna Menozzi Cristina Mussini Giovanni Guaraldi Jordan E. Lake |
| author_facet | Paula Debroy Han Feng Hongyu Miao Jovana Milic Guido Ligabue Stefano Draisci Giulia Besutti Federica Carli Marianna Menozzi Cristina Mussini Giovanni Guaraldi Jordan E. Lake |
| author_sort | Paula Debroy |
| collection | DOAJ |
| description | Background: Treatment with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain, however the long-term effect of INSTI-based regimens on adipose tissue (AT) compartments remains unknown. Objectives: To evaluate the effect of switching to an INSTI on visceral (VAT) and subcutaneous (SAT) AT in virologically-suppressed adults with HIV. Methods: We performed a retrospective observational cohort study of ART experienced adults referred to the metabolic Clinic of the University of Modena and Reggio Emilia who had ≥2 assessments of body composition by abdominal computed tomography. An interrupted time series model with mixed-effect model incorporated was used to calculate VAT and SAT change rate, adjusting for smoking status, use of alcohol, and physical activity. Results: A total of 698 patients were included: 156 who switched to an INSTI-based regimen and 542 who did not. After switch to INSTI, mean SAT area increased approximately 3-fold (before 0.27 vs after 0.73 cm2/month; p = 0.011), and VAT area 7-fold (0.18 vs 1.30 cm2/month; p < 0.001). Conclusions: Among PLWH on ART, both SAT and VAT gain accelerated after switching to an INSTI-based regimen. The associations between INSTIs and central adiposity require further investigation. |
| first_indexed | 2024-03-11T18:40:17Z |
| format | Article |
| id | doaj.art-e88111a074704054964d19ecb4681a56 |
| institution | Directory Open Access Journal |
| issn | 2578-7470 |
| language | English |
| last_indexed | 2024-03-11T18:40:17Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | HIV Research & Clinical Practice |
| spelling | doaj.art-e88111a074704054964d19ecb4681a562023-10-12T13:43:52ZengTaylor & Francis GroupHIV Research & Clinical Practice2578-74702020-11-0121616817310.1080/25787489.2020.18481311848131Changes in central adipose tissue after switching to integrase inhibitorsPaula Debroy0Han Feng1Hongyu Miao2Jovana MilicGuido Ligabue3Stefano Draisci4Giulia Besutti5Federica Carli6Marianna Menozzi7Cristina Mussini8Giovanni Guaraldi9Jordan E. Lake10University of Texas Health Sciences CenterUniversity of Texas Health Sciences CenterUniversity of Texas Health Sciences CenterUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Texas Health Sciences CenterBackground: Treatment with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain, however the long-term effect of INSTI-based regimens on adipose tissue (AT) compartments remains unknown. Objectives: To evaluate the effect of switching to an INSTI on visceral (VAT) and subcutaneous (SAT) AT in virologically-suppressed adults with HIV. Methods: We performed a retrospective observational cohort study of ART experienced adults referred to the metabolic Clinic of the University of Modena and Reggio Emilia who had ≥2 assessments of body composition by abdominal computed tomography. An interrupted time series model with mixed-effect model incorporated was used to calculate VAT and SAT change rate, adjusting for smoking status, use of alcohol, and physical activity. Results: A total of 698 patients were included: 156 who switched to an INSTI-based regimen and 542 who did not. After switch to INSTI, mean SAT area increased approximately 3-fold (before 0.27 vs after 0.73 cm2/month; p = 0.011), and VAT area 7-fold (0.18 vs 1.30 cm2/month; p < 0.001). Conclusions: Among PLWH on ART, both SAT and VAT gain accelerated after switching to an INSTI-based regimen. The associations between INSTIs and central adiposity require further investigation.http://dx.doi.org/10.1080/25787489.2020.1848131insticentral adiposityweightfat |
| spellingShingle | Paula Debroy Han Feng Hongyu Miao Jovana Milic Guido Ligabue Stefano Draisci Giulia Besutti Federica Carli Marianna Menozzi Cristina Mussini Giovanni Guaraldi Jordan E. Lake Changes in central adipose tissue after switching to integrase inhibitors HIV Research & Clinical Practice insti central adiposity weight fat |
| title | Changes in central adipose tissue after switching to integrase inhibitors |
| title_full | Changes in central adipose tissue after switching to integrase inhibitors |
| title_fullStr | Changes in central adipose tissue after switching to integrase inhibitors |
| title_full_unstemmed | Changes in central adipose tissue after switching to integrase inhibitors |
| title_short | Changes in central adipose tissue after switching to integrase inhibitors |
| title_sort | changes in central adipose tissue after switching to integrase inhibitors |
| topic | insti central adiposity weight fat |
| url | http://dx.doi.org/10.1080/25787489.2020.1848131 |
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