Fibroblast Growth Factor (FGF) Receptor Mutations: A Pathway to Understanding Multigenic Risk in Disease?

Fibroblast Growth Factor (FGF) Receptor Mutations: A Pathway to Understanding Multigenic Risk in Disease?

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Fibroblast growth factor receptor (FGFR) gain-of-function mutations form the pathogenic basis of multiple congenital pathologies. A pioneering body of work over the past two decades has established that a unique mutation selection process within the testis likely underlies the paternal age effect ch...

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Bibliographic Details
Main Author: Stuart J. Mires
Format: Article
Language:English
Published: University Library System, University of Pittsburgh 2013-12-01
Series:International Journal of Medical Students
Subjects:
fibroblast growth factors
acrocephalosyndactylia
craniosynostoses
germ-line mutation
Online Access:http://ijms.info/IJMS/article/view/219

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